Curcumin Induces Pyroptosis-Associated Molecular Changes in Osteosarcoma Cells Correlating with the ROS/NLRP3/CASPASE-1/GSDMD Axis with Concomitant PI3K/AKT Suppression and Apoptosis Activation.

Keqing Yuan, Xingyu Zhao, Jiayi Guo, Yue Lu, Yufei Cui, Wei Zhang, Wenhe Zhu

Abstract read

In one paragraph

Article in Nutrients, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Damage-Associated Molecular Patterns in Mesothelioma: Drivers of Inflammation and Therapeutic Targets.International journal of molecular sciences · 2026
Review

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Keqing YuanJilin Provincial Technology Collaborative Innovation Center of Hypobaric Hypoxia, School of Basic Medical Sciences, Jilin Medical University, Jilin 132013, China.

Xingyu ZhaoDepartment of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Jilin Medical University, Jilin 132013, China.

Jiayi GuoDepartment of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Jilin Medical University, Jilin 132013, China.ORCID 0009-0002-6180-0223

Yue LuDepartment of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Jilin Medical University, Jilin 132013, China.

Yufei CuiGraduate School of Medicine, Tohoku University, Sendai 980-8575, Japan.

Wei ZhangDepartment of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Jilin Medical University, Jilin 132013, China.

Wenhe ZhuDepartment of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Jilin Medical University, Jilin 132013, China.

Funding

Jilin Province Science and Technology Department YDZJ202301ZYTS111

6 · The paper itself

Abstract

Curcumin, a natural polyphenolic compound derived from turmeric, exhibits broad-spectrum anticancer activities, but its ability to induce pyroptosis in osteosarcoma remains unknown. Osteosarcoma is the most common primary malignant bone tumor in children and adolescents, and novel therapeutic strategies are urgently needed to overcome osteosarcoma chemoresistance.

Indexed as

ApoptosisBone NeoplasmsCurcuminOsteosarcomaPyroptosisCaspase 1Cell Line, TumorCell SurvivalGasderminsHumansIntracellular Signaling Peptides and ProteinsMembrane Potential, MitochondrialNLR Family, Pyrin Domain-Containing 3 ProteinPhosphate-Binding ProteinsPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktCaspase 1CurcuminGasderminsGSDMD protein, humanIntracellular Signaling Peptides and ProteinsNLR Family, Pyrin Domain-Containing 3 ProteinNLRP3 protein, humanPhosphate-Binding ProteinsPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktReactive Oxygen SpeciescurcuminGSDMDNLRP3 inflammasomeosteosarcomapyroptosis

Identifiers

PMID42280476

DOI10.3390/nu18111831

PMCPMC13259424

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.