Evidence map›Paper›PMID 42280389›Full record

ArticleNutrients2026

Adolescent and Maternal Mediterranean Diet During Pregnancy Is Associated with Anxiety Symptoms in Early Adolescence: Results from the KLOTHO Cohort.

Spyridon N Karras, Maria Dalamaga, Maria Kypraiou, Vikentia Harizopoulou, Antonios Vlastos, Marios Anemoulis, Neoklis Georgopoulos, Georgios Mastorakos, Dimitrios G Goulis

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Article in Nutrients, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Spyridon N KarrasLaboratory of Biological Chemistry, Medical School, Aristotle University, 55535 Thessaloniki, Greece.ORCID 0000-0002-4225-2746
Maria DalamagaDepartment of Biological Chemistry, School of Medicine, National and Kapodistrian University of Athens, 10679 Athens, Greece.ORCID 0000-0002-7008-388X
Maria KypraiouAssisting Nature Centre of Reproduction and Genetics, 57001 Thessaloniki, Greece.
Vikentia HarizopoulouDepartment of Midwifery, Faculty of Health and Caring Sciences, University of West Attica, 12243 Athens, Greece.ORCID 0009-0001-6004-1205
Antonios VlastosMedical School, Aristotle University, 55535 Thessaloniki, Greece.ORCID 0000-0001-6901-744X
Marios AnemoulisMedical School, Aristotle University, 55535 Thessaloniki, Greece.ORCID 0000-0002-5804-4669
Neoklis GeorgopoulosDivision of Endocrinology, Department of Internal Medicine, School of Health Sciences, University of Patras, 26504 Patras, Greece.
Georgios MastorakosSecond Department of Surgery, Medical School, Aretaieio Athens Hospital, National and Kapodistrian University of Athens, 11528 Athens, Greece.ORCID 0000-0002-1929-3275
Dimitrios G GoulisUnit of Reproductive Endocrinology, 1st Department of Obstetrics and Gynecology, Medical School, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.ORCID 0000-0002-5005-1995

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAdolescence is a critical developmental period for emotional health, and anxiety disorders are a major public health concern. Adherence to the Mediterranean diet has been associated with improved mental health outcomes in adults; however, evidence in adolescents remains limited.

methodsWe analyzed data from 86 adolescents participating in the KLOTHO birth cohort. Dietary quality was assessed using the KIDMED index, whereas maternal adherence to the Mediterranean diet during pregnancy was evaluated using a Mediterranean diet score. Psychological outcomes included behavioral difficulties (Strengths and Difficulties Questionnaire), anxiety symptoms (Spence Children's Anxiety Scale), and mood-related outcomes (Mood and Feelings Questionnaire). Associations were examined using Spearman's correlation analyses and multivariate linear regression models adjusted for sex, body mass index (BMI), sleep duration, and physical activity.

resultsHigher adherence to the Mediterranean diet in adolescents was inversely associated with anxiety levels in correlation analyses (ρ = -0.294,

conclusionsAdherence to the Mediterranean diet during adolescence is modestly associated with lower levels of specific anxiety symptoms, suggesting a modest domain-specific association between dietary patterns and emotional health.

Indexed as

AnxietyDiet, MediterraneanMaternal Nutritional Physiological PhenomenaAdolescentBirth CohortCohort StudiesFemaleHumansMalePregnancySurveys and Questionnairesadolescenceanxietyanxiety adolescentsbirth cohortdietary patternsKIDMEDKLOTHO cohortmaternal dietMediterranean dietmental healthnutritional psychiatry

Identifiers

PMID42280389
PMCPMC13259179

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