ArticleNutrients2026
Understanding Obesity in Individuals with Down Syndrome: Caregiver Perceptions, Awareness, and Motivation.
Thomas Cahill, Valerie Nalesso, Pat Clarke, Maria Martinez de Lagran, Andre Strydom, Li Chan, Marie-Claude Potier, Johannes Beckers, Klaus Langohr, Pietro Liò and 6 more
Abstract read
In one paragraphArticle in Nutrients, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
16 authors.
Thomas CahillCentre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, 08003 Barcelona, Spain.
Valerie NalessoInstitut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), UMR7104, U1258, Université de Strasbourg, CNRS, INSERM, 67400 Strasbourg, France.
Pat ClarkeEuropean Down Syndrome Association, 1210 Brussels, Belgium.
Maria Martinez de LagranCentre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, 08003 Barcelona, Spain.ORCID 0000-0002-0836-6491 Andre StrydomInstitute of Psychiatry, Psychology, and Neuroscience, King's College London, London SE5 8AF, UK.
Li ChanCentre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK.
Marie-Claude PotierParis Brain Institute (ICM), Pitié-Salpêtrière Hospital, 75013 Paris, France.
Johannes BeckersInstitute of Experimental Genetics, Helmholtz Zentrum München-German Research Centre for Environmental Health, Ingolstaedter Landstr. 1, 85764 Neuherberg, Germany.ORCID 0000-0001-7874-3822 Klaus LangohrIntegrative Pharmacology and Systems Neuroscience Research Group, Neuroscience Research Program, Hospital del Mar Research Institute, 08003 Barcelona, Spain.ORCID 0000-0001-7075-9192 Pietro LiòDepartment of Computer Science and Technology, University of Cambridge, Cambridge CB3 0FD, UK.ORCID 0000-0002-0540-5053 Rafael de La TorreIntegrative Pharmacology and Systems Neuroscience Research Group, Neuroscience Research Program, Hospital del Mar Research Institute, 08003 Barcelona, Spain.
Laura ForcanoIntegrative Pharmacology and Systems Neuroscience Research Group, Neuroscience Research Program, Hospital del Mar Research Institute, 08003 Barcelona, Spain.
Yann HéraultInstitut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), UMR7104, U1258, Université de Strasbourg, CNRS, INSERM, 67400 Strasbourg, France.ORCID 0000-0001-7049-6900 Mara DierssenCentre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, 08003 Barcelona, Spain.ORCID 0000-0003-0853-6865 Go-Ds Consortium
Funding
Agencia Estatal de Investigación PID2022-141900OB-I00European Union 848077Fondation Jérôme-Lejeune 2002Generalitat de Catalunya SGR2023Marató TV3 202212-30Medical Research Council MR/S011277/1, MR/S005145/1, and MR/R024901/1Ministerio de Ciencia, Innovación y Universidades CEX2020-001049-S, MCIN/AEI/10.13039/501100011033Ministerio de Ciencia, Innovación y Universidades RTC2019-007230-1, RTC2019-007329-1; and CPP2022-009659Wellcome Trust 217543/Z/19/Z
6 · The paper itselfAbstract
backgroundIndividuals with Down syndrome (DS) are at an increased risk of obesity and, subsequently, its cardiometabolic and cognitive impacts. Caregivers play a critical role in managing health, yet their perceptions and behaviors have been poorly characterized.
methodsWe performed a cross-sectional online survey of caregivers (
resultsAround one-third (32%) of caregivers perceived their family member with DS with obesity. Perceived obesity changed with age and was more frequently reported in female family members with DS. Awareness of general metabolic risk factors was high among caregivers, but half of respondents were unaware that abdominal fat affects brain health. Consultation with healthcare professionals was uncommon (57% "Never/Rarely/Sometimes") even among those perceived with obesity.
conclusionsCaregivers demonstrate good general awareness about high energy food risks but limited knowledge of the link between obesity and brain health. Enhancing caregiver education and supporting behavioral change could promote healthier lifestyles in families with individuals with DS.
Indexed as
CaregiversDown SyndromeHealth Knowledge, Attitudes, PracticeMotivationObesityAdultAgedAwarenessCross-Sectional StudiesFemaleHealth BehaviorHumansMaleMiddle AgedPerceptionRisk Factorscaregiverscross-sectional surveydown syndromemotivationobesity awarenessobesity perceptionsprofessional consultationrisk awareness
Identifiers
PMID42280370
PMCPMC13258468
What OpenQuestion holds
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