Evidence map›Paper›PMID 42280336›Full record

ArticleNutrients2026

Caregiver-Associated Physical Activity Patterns, Dietary Behaviors and Interventional Beliefs in Individuals with Down Syndrome: Insights from a Large European Survey.

Thomas Cahill, Valerie Nalesso, Pat Clarke, Maria Martinez de Lagran, Andre Strydom, Li Chan, Marie-Claude Potier, Johannes Beckers, Klaus Langohr, Pietro Liò and 6 more

Abstract read
In one paragraph

Article in Nutrients, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Thomas CahillCentre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Dr. Aiguader 88, 08003 Barcelona, Spain.
Valerie NalessoInstitut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), INSERM, CNRS, Université de Strasbourg, UMR7104, U1258, 67404 Illkirch-Graffenstaden, France.
Pat ClarkeEuropean Down Syndrome Association, 1210 Brussels, Belgium.
Maria Martinez de LagranCentre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Dr. Aiguader 88, 08003 Barcelona, Spain.ORCID 0000-0002-0836-6491
Andre StrydomInstitute of Psychiatry, Psychology, and Neuroscience, King's College London, London SE5 8AB, UK.
Li ChanCentre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK.
Marie-Claude PotierInstitut du Cerveau-Paris Brain Institute-ICM, CNRS, APHP, Hôpital de La Pitié Salpêtrière, Inserm, Sorbonne Université, 75013 Paris, France.ORCID 0000-0003-2462-7150
Johannes BeckersInstitute of Experimental Genetics, German Research Centre for Environmental Health, Helmholtz Zentrum München, Ingolstaedter Landstr. 1, 85764 Neuherberg, Germany.ORCID 0000-0001-7874-3822
Klaus LangohrIntegrative Pharmacology and Systems Neuroscience Research Group, Neuroscience Research Program, Hospital del Mar Research Institute, 08003 Barcelona, Spain.ORCID 0000-0001-7075-9192
Pietro LiòDepartment of Computer Science and Technology, University of Cambridge, Cambridge CB3 0FD, UK.ORCID 0000-0002-0540-5053
Rafael de La TorreIntegrative Pharmacology and Systems Neuroscience Research Group, Neuroscience Research Program, Hospital del Mar Research Institute, 08003 Barcelona, Spain.
Laura ForcanoIntegrative Pharmacology and Systems Neuroscience Research Group, Neuroscience Research Program, Hospital del Mar Research Institute, 08003 Barcelona, Spain.
Anne Hiance-DelahayeInstitut Jérôme Lejeune, 75015 Paris, France.ORCID 0000-0002-9932-0754
Yann HéraultInstitut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), INSERM, CNRS, Université de Strasbourg, UMR7104, U1258, 67404 Illkirch-Graffenstaden, France.ORCID 0000-0001-7049-6900
Mara DierssenCentre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Dr. Aiguader 88, 08003 Barcelona, Spain.ORCID 0000-0003-0853-6865
Go-Ds Consortium

Funding

Agencia Estatal de Investigación PID2022-141900OB-I00 INTO-DSBarts Charity G-002162European Union 848077Generalitat de Catalunya Grups consolidats 2023Marato TV3 202212-30Medical Research Council MR/S011277/1, MR/S005145/1, and MR/R024901/1Ministerio de Ciencia, Innovación y Universidades CEX2020-001049-S, MCIN/AEI/10.13039/501100011033Ministerio de Ciencia, Innovación y Universidades RTC2019-007230-1, RTC2019-007329-1; and CPP2022-009659Wellcome Trust 217543/Z/19/Z
6 · The paper itself

Abstract

backgroundLifestyle factors such as diet and physical activity significantly impact on the risk of obesity in individuals with Down syndrome (DS). However, in the absence of national nutritional guidelines in individuals with DS, further work is needed to understand their dietary and physical activity patterns. In this work we retrieved caregivers' responses on those aspects.

methodsWe analyzed data from a cross-sectional online survey of caregivers of individuals with DS conducted as part of the GO-DS21 project and reported in the accompanying paper (nutrients-4216283) (n = 764). We explored physical activity patterns, dietary habits, beliefs around weight-loss interventions and caregiver confidence that family members with DS would engage in a healthier lifestyle. Associations were examined using correlation analysis, and cumulative and binary logistic regression models.

resultsCaregivers reported that most individuals with DS exercised 1-3 times per week, with frequency declining with age. Males were more likely to exercise daily than females. Caregiver exercise frequency was positively correlated with that of their DS family member (ρ = 0.521,

conclusionsIn this large European caregiver survey, reported consumption of selected energy-dense foods was generally low, although fried food intake and higher snack frequency were associated with perceived obesity. Physical activity patterns were closely aligned between caregivers and individuals with DS, suggesting shared household health behaviors. These findings highlight the importance of involving caregivers and family environments in lifestyle interventions aimed at supporting physical activity and weight management in individuals with DS.

Indexed as

CaregiversDietDown SyndromeExerciseFeeding BehaviorHealth Knowledge, Attitudes, PracticeAdultCross-Sectional StudiesEuropeFemaleHealth BehaviorHumansMaleMiddle AgedObesitySurveys and Questionnairescaregiver confidencedietDown syndromeinterventionsobesityphysical activity

Identifiers

PMID42280336
PMCPMC13258397

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.