Stereoselective Synthesis of Topologically Chiral Knots and Links: Synthesis and Applications.

Benteng Ma, Yan Sun, Haifeng Tian, Xiao Zhang, Yuheng Ju, Saiwen Gao, Lin Wu

Abstract readReview

In one paragraph

Review in Molecules (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

7 authors.

Benteng MaHigh Purity Chemistry Science and Technology Innovation Center of Jilin Province, Center of Analysis and Measurement, Jilin University of Chemical Technology, 45 Chengde Street, Jilin 132022, China.

Yan SunKey Laboratory of Chemical Waste Resource Utilization of Jilin Province, School of Resources and Environment Engineering, Jilin University of Chemical Technology, 45 Chengde Street, Jilin 132022, China.

Haifeng TianHigh Purity Chemistry Science and Technology Innovation Center of Jilin Province, Center of Analysis and Measurement, Jilin University of Chemical Technology, 45 Chengde Street, Jilin 132022, China.

Xiao ZhangHigh Purity Chemistry Science and Technology Innovation Center of Jilin Province, Center of Analysis and Measurement, Jilin University of Chemical Technology, 45 Chengde Street, Jilin 132022, China.

Yuheng JuHigh Purity Chemistry Science and Technology Innovation Center of Jilin Province, Center of Analysis and Measurement, Jilin University of Chemical Technology, 45 Chengde Street, Jilin 132022, China.

Saiwen GaoHigh Purity Chemistry Science and Technology Innovation Center of Jilin Province, Center of Analysis and Measurement, Jilin University of Chemical Technology, 45 Chengde Street, Jilin 132022, China.

Lin WuHigh Purity Chemistry Science and Technology Innovation Center of Jilin Province, Center of Analysis and Measurement, Jilin University of Chemical Technology, 45 Chengde Street, Jilin 132022, China.ORCID 0000-0001-5638-7863

Funding

Natural Science Foundation of Jilin Province YDZJ202401555ZYTSProject of Jilin Education Department JJKH20251306KJ

6 · The paper itself

Abstract

Topologically chiral molecular knots and links represent a unique class of stereochemical architectures in which handedness is encoded by the global crossing pattern of an entangled framework rather than by a local stereogenic element. Their configurational robustness and shape-persistent chiral environments make them promising platforms for molecular recognition, catalysis, chiroptical response, and spin-selective transport. This review summarizes recent progress in the stereoselective synthesis of topologically chiral knots and links, with emphasis on chirality transfer from point, axial and helical elements into persistent topological handedness. Major synthetic strategies are organized into helicity-driven approaches, template-free dynamic systems, coordination-driven self-assembly, and chiral self-sorting. The applications of knots in host-guest confinement, asymmetric catalysis, chiral recognition, and spin-selective transport are also discussed.

Indexed as

molecular knotsmolecular linkstopological chirality

Identifiers

PMID42280255

DOI10.3390/molecules31111953

PMCPMC13258784

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