ArticleMolecules (Basel, Switzerland)2026
Delta-3-Carene Presented Anti-Inflammatory and Antinociceptive Properties by Modulating Leukocyte Activation in the Experimental Inflammatory Response In Vitro and In Vivo.
Paloma Kênia de Moraes Berenguel Lossavaro, Mila Marluce Lima Fernandes, Iluska Senna Bonfá, Joyce Dos Santos Lencina, Dalila Dos Santos Lencina, Gabriel Silvino de Oliveira Venâncio, Fernanda Sordi Diniz, Lucas Luiz Machado, Josyelen Lousada Felipe, Luiz Alexandre Marques Wiirzler and 4 more
Abstract read
In one paragraphArticle in Molecules (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
14 authors.
Paloma Kênia de Moraes Berenguel LossavaroPharmaceutical Sciences, Food and Nutrition College, Federal University of Mato Grosso do Sul (UFMS), Campo Grande 79070-900, MS, Brazil.ORCID 0009-0001-6074-4621 Mila Marluce Lima FernandesPharmaceutical Sciences, Food and Nutrition College, Federal University of Mato Grosso do Sul (UFMS), Campo Grande 79070-900, MS, Brazil.ORCID 0000-0002-4301-6884 Iluska Senna BonfáPharmaceutical Sciences, Food and Nutrition College, Federal University of Mato Grosso do Sul (UFMS), Campo Grande 79070-900, MS, Brazil.ORCID 0000-0002-4652-3267 Joyce Dos Santos LencinaPharmaceutical Sciences, Food and Nutrition College, Federal University of Mato Grosso do Sul (UFMS), Campo Grande 79070-900, MS, Brazil.ORCID 0000-0002-2520-8356 Dalila Dos Santos LencinaPharmaceutical Sciences, Food and Nutrition College, Federal University of Mato Grosso do Sul (UFMS), Campo Grande 79070-900, MS, Brazil.ORCID 0009-0009-7564-7160 Gabriel Silvino de Oliveira VenâncioPharmaceutical Sciences, Food and Nutrition College, Federal University of Mato Grosso do Sul (UFMS), Campo Grande 79070-900, MS, Brazil.ORCID 0009-0004-0225-2129 Fernanda Sordi DinizPharmaceutical Sciences, Food and Nutrition College, Federal University of Mato Grosso do Sul (UFMS), Campo Grande 79070-900, MS, Brazil.ORCID 0009-0003-2404-3283 Lucas Luiz MachadoPharmaceutical Sciences, Food and Nutrition College, Federal University of Mato Grosso do Sul (UFMS), Campo Grande 79070-900, MS, Brazil.ORCID 0009-0005-1956-0248 Josyelen Lousada FelipePharmaceutical Sciences, Food and Nutrition College, Federal University of Mato Grosso do Sul (UFMS), Campo Grande 79070-900, MS, Brazil.ORCID 0009-0006-4988-7804 Luiz Alexandre Marques WiirzlerDepartment of Pharmacology and Therapeutics, State University of Maringá (Universidade Estadual de Maringá-UEM), Maringá 87020-900, PR, Brazil.ORCID 0000-0003-0520-681X Cândida Aparecida Leite KassuyaHealth Sciences College, Federal University of Grande Dourados (UFGD), Dourados 79804-970, MS, Brazil.ORCID 0000-0002-8998-9219 Carlos Alexandre CarolloPharmaceutical Sciences, Food and Nutrition College, Federal University of Mato Grosso do Sul (UFMS), Campo Grande 79070-900, MS, Brazil.ORCID 0000-0003-1231-9441 Mônica Cristina Toffoli-KadriPharmaceutical Sciences, Food and Nutrition College, Federal University of Mato Grosso do Sul (UFMS), Campo Grande 79070-900, MS, Brazil.ORCID 0000-0003-4160-4444 Saulo Euclides Silva-FilhoPharmaceutical Sciences, Food and Nutrition College, Federal University of Mato Grosso do Sul (UFMS), Campo Grande 79070-900, MS, Brazil.ORCID 0000-0002-9676-7622 Funding
Coordenação de Aperfeicoamento de Pessoal de Nível Superior Finance Code 001
6 · The paper itselfAbstract
Delta-3-carene (CAR), a monoterpene derived from plant essential oils, exhibits promising biological properties, including anti-inflammatory, antioxidative, anxiolytic, and antimicrobial activities. Therefore, this study aimed to investigate the anti-inflammatory effects of CAR by analyzing the activity of this terpene on leukocyte activation through the evaluation of cell migration in in vitro and in vivo models. Cell viability analysis demonstrated that CAR (3, 10, 30, and 90 μg/mL) exerted no cytotoxic effects and significantly reduced in vitro neutrophil chemotaxis toward
Indexed as
AnalgesicsAnti-Inflammatory AgentsInflammationLeukocytesAnimalsCarrageenanDisease Models, AnimalEdemaFreund's AdjuvantHyperalgesiaMaleMiceNeutrophilsPeritonitisPhagocytosisZymosanAnalgesicsAnti-Inflammatory AgentsCarrageenanFreund's AdjuvantZymosandelta-3-careneinflammationleukocyte activationpainterpene
Identifiers
PMID42280218
PMCPMC13439039
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