ArticleMolecules (Basel, Switzerland)2026
Botanical Origin-Dependent Phytochemical Profiles and Pharmaceutical Properties of Medical-Grade Honeys: Transdermal Delivery and Antibacterial Efficacy in a Wound Fluid Model.
Anna Nowak, Wojciech Żwierełło, Izabela Gutowska, Anna Muzykiewicz-Szymańska, Edyta Kucharska, Jana Godocikova, Viktoriia Chirkova, Łukasz Kucharski, Katarzyna Piotrowska, Karolina Jakubczyk and 2 more
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In one paragraphArticle in Molecules (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
12 authors.
Anna NowakDepartment of Cosmetic and Pharmaceutical Chemistry, Pomeranian Medical University in Szczecin, 70-111 Szczecin, Poland.ORCID 0000-0002-4287-6751 Wojciech ŻwierełłoDepartment of Medical Chemistry, Pomeranian Medical University in Szczecin, 70-111 Szczecin, Poland.ORCID 0000-0001-5987-7120 Izabela GutowskaDepartment of Medical Chemistry, Pomeranian Medical University in Szczecin, 70-111 Szczecin, Poland.
Anna Muzykiewicz-SzymańskaDepartment of Cosmetic and Pharmaceutical Chemistry, Pomeranian Medical University in Szczecin, 70-111 Szczecin, Poland.ORCID 0000-0003-1880-1140 Edyta KucharskaDepartment of Organic Chemical Technology and Polymer Materials, Faculty of Chemical Technology and Engineering, West Pomeranian University of Technology in Szczecin, 70-322 Szczecin, Poland.ORCID 0000-0002-6380-5848 Jana GodocikovaLaboratory of Apidology and Apitherapy, Department of Microbial Genetics, Institute of Molecular Biology, Slovak Academy of Sciences, 845 51 Bratislava, Slovakia.
Viktoriia ChirkovaLaboratory of Apidology and Apitherapy, Department of Microbial Genetics, Institute of Molecular Biology, Slovak Academy of Sciences, 845 51 Bratislava, Slovakia.
Łukasz KucharskiDepartment of Cosmetic and Pharmaceutical Chemistry, Pomeranian Medical University in Szczecin, 70-111 Szczecin, Poland.ORCID 0000-0003-3295-5023 Katarzyna PiotrowskaDepartment of Physiology, Pomeranian Medical University in Szczecin, 70-111 Szczecin, Poland.ORCID 0000-0002-4472-0830 Karolina JakubczykDepartment of Human Nutrition and Metabolomics, Pomeranian Medical University in Szczecin, 71-460 Szczecin, Poland.ORCID 0000-0002-5853-9709 Kinga SzymczykowskaDepartment of Human Nutrition and Metabolomics, Pomeranian Medical University in Szczecin, 71-460 Szczecin, Poland.
Juraj MajtanLaboratory of Apidology and Apitherapy, Department of Microbial Genetics, Institute of Molecular Biology, Slovak Academy of Sciences, 845 51 Bratislava, Slovakia.ORCID 0000-0002-7268-1584 Funding
Ministry of Education, Science, Research and Sport of the Slovak Republic VEGA 2/0011/26Slovak Research and Development Agency APVV-21-0262
6 · The paper itselfAbstract
Medical-grade honeys (MGHs) are clinically applied therapeutic agents for wound management; however, their bioactive constituent profiles and biological performance in complex wound environments remain incompletely characterized. This study evaluated the wound-healing potential, antibacterial efficacy, and transdermal penetration capacity of three commercially available MGHs: manuka (MH), chestnut (ChH), and multifloral honey (MFH). MGHs were characterized for antioxidant capacity (DPPH and ABTS), total phenolic content (TPC), and phytochemical composition by HPLC and GC-MS. Wound healing activity was assessed using a scratch assay, transdermal penetration of phenolic acids through porcine skin using Franz diffusion cells, and antibacterial efficacy by MIC assay with and without artificial wound fluid exudate. H
Indexed as
Anti-Bacterial AgentsHoneyPhytochemicalsWound HealingAdministration, CutaneousAnimalsAntioxidantsHydrogen PeroxideMicrobial Sensitivity TestsPhenolsSkinSwineAnti-Bacterial AgentsAntioxidantsHydrogen PeroxidePhenolsPhytochemicalsantibacterial activityhoneyphytochemicalspolyphenolsskinwound
Identifiers
PMID42280166
PMCPMC13257883
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