Evidence map›Paper›PMID 42280143›Full record

ArticleMolecules (Basel, Switzerland)2026

Synthesis of Methoxylated Benzoxanthones as Drug Metabolites of Antischistosomal Schistodiones-A Limited Environmental Risk.

Elena Cesar-Rodo, Jeremy Boilevin, Jimmy Richard, Peter D Ziniel, Didier Belorgey, Louis Maes, Francesco Angelucci, David Lee Williams, Elisabeth Davioud-Charvet, Don Antoine Lanfranchi

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Elena Cesar-RodoLaboratoire d'Innovation Moléculaire et Applications (LIMA), UMR7042 CNRS-Université de Strasbourg-Université Haute-Alsace, Team Bio(IN)organic & Medicinal Chemistry, European School of Chemistry, Polymers and Materials (ECPM), 25, Rue Becquerel, F-67087 Strasbourg, France.
Jeremy BoilevinLaboratoire d'Innovation Moléculaire et Applications (LIMA), UMR7042 CNRS-Université de Strasbourg-Université Haute-Alsace, Team Bio(IN)organic & Medicinal Chemistry, European School of Chemistry, Polymers and Materials (ECPM), 25, Rue Becquerel, F-67087 Strasbourg, France.
Jimmy RichardLaboratoire d'Innovation Moléculaire et Applications (LIMA), UMR7042 CNRS-Université de Strasbourg-Université Haute-Alsace, Team Bio(IN)organic & Medicinal Chemistry, European School of Chemistry, Polymers and Materials (ECPM), 25, Rue Becquerel, F-67087 Strasbourg, France.
Peter D ZinielDepartment of Microbial Pathogens and Immunity, Rush University Medical Center, 1735 West Harrison Street, Chicago, IL 60612, USA.
Didier BelorgeyLaboratoire d'Innovation Moléculaire et Applications (LIMA), UMR7042 CNRS-Université de Strasbourg-Université Haute-Alsace, Team Bio(IN)organic & Medicinal Chemistry, European School of Chemistry, Polymers and Materials (ECPM), 25, Rue Becquerel, F-67087 Strasbourg, France.
Louis MaesLaboratory of Microbiology, Parasitology and Hygiene (LMPH), Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, Universiteitsplein 1, B-2610 Antwerp, Belgium.ORCID 0000-0002-2324-9509
Francesco AngelucciDepartment of Life, Health and Environmental Sciences, University of L'Aquila, 67100 L'Aquila, Italy.ORCID 0000-0001-7305-7903
David Lee WilliamsDepartment of Microbial Pathogens and Immunity, Rush University Medical Center, 1735 West Harrison Street, Chicago, IL 60612, USA.ORCID 0000-0002-6815-4909
Elisabeth Davioud-CharvetLaboratoire d'Innovation Moléculaire et Applications (LIMA), UMR7042 CNRS-Université de Strasbourg-Université Haute-Alsace, Team Bio(IN)organic & Medicinal Chemistry, European School of Chemistry, Polymers and Materials (ECPM), 25, Rue Becquerel, F-67087 Strasbourg, France.ORCID 0000-0001-7026-4034
Don Antoine LanfranchiLaboratoire d'Innovation Moléculaire et Applications (LIMA), UMR7042 CNRS-Université de Strasbourg-Université Haute-Alsace, Team Bio(IN)organic & Medicinal Chemistry, European School of Chemistry, Polymers and Materials (ECPM), 25, Rue Becquerel, F-67087 Strasbourg, France.

Funding

Laboratoire d'Excellence (LabEx) ParaFrap ANR-11-LABX-0024NIH HHS 1R01AI065622-01A2
6 · The paper itself

Abstract

In the search for new antischistosomal 3-benzylmenadiones (benzylMDs), the screening of a library developed in our laboratory led to the identification of two regioisomeric analogues, the 2',5'- and 3',5'-dimethoxy-benzylMD-designated schistodiones A

Indexed as

Schistosoma mansoniSchistosomicidesXanthonesAnimalsSchistosomicidesXanthones3-benzylmenadioneantiplasmodialantischistosomalbenzoxanthonenucleophilic aromatic substitution SNAroxidative phenolic couplingprodrug

Identifiers

PMID42280143
PMCPMC13258496

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.