Evidence map›Paper›PMID 42279718›Full record

ArticleFoods (Basel, Switzerland)2026

Brewer's Spent Grain Flour: Chemical Composition, Functional Properties, and Influence on Gut Microbiota.

Cristina Clavel, Vanesa Núñez-Gómez, Nieves Baenas, Rocío González-Barrio, Belén Olga Ferrando, Lorena Sánchez-Martínez, Marina Santaella, María Jesús Periago

Abstract read
In one paragraph

Article in Foods (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Cristina ClavelDepartment of Food Science and Nutrition, Faculty of Veterinary Sciences, University of Murcia, Campus of International Excellence "Campus Mare Nostrum", Campus of Espinardo, Espinardo, 30.100 Murcia, Spain.ORCID 0009-0005-8003-233X
Vanesa Núñez-GómezDepartment of Food Science and Nutrition, Faculty of Veterinary Sciences, University of Murcia, Campus of International Excellence "Campus Mare Nostrum", Campus of Espinardo, Espinardo, 30.100 Murcia, Spain.ORCID 0000-0001-6564-1130
Nieves BaenasDepartment of Food Science and Nutrition, Faculty of Veterinary Sciences, University of Murcia, Campus of International Excellence "Campus Mare Nostrum", Campus of Espinardo, Espinardo, 30.100 Murcia, Spain.ORCID 0000-0001-7404-2623
Rocío González-BarrioDepartment of Food Science and Nutrition, Faculty of Veterinary Sciences, University of Murcia, Campus of International Excellence "Campus Mare Nostrum", Campus of Espinardo, Espinardo, 30.100 Murcia, Spain.ORCID 0000-0002-6648-5229
Belén Olga FerrandoDepartment of Food Science and Nutrition, Faculty of Veterinary Sciences, University of Murcia, Campus of International Excellence "Campus Mare Nostrum", Campus of Espinardo, Espinardo, 30.100 Murcia, Spain.ORCID 0000-0002-7226-7818
Lorena Sánchez-MartínezDepartment of Food Science and Nutrition, Faculty of Veterinary Sciences, University of Murcia, Campus of International Excellence "Campus Mare Nostrum", Campus of Espinardo, Espinardo, 30.100 Murcia, Spain.ORCID 0000-0001-9167-5510
Marina SantaellaDepartment of Food Science and Nutrition, Faculty of Veterinary Sciences, University of Murcia, Campus of International Excellence "Campus Mare Nostrum", Campus of Espinardo, Espinardo, 30.100 Murcia, Spain.ORCID 0000-0003-1708-2893
María Jesús PeriagoDepartment of Food Science and Nutrition, Faculty of Veterinary Sciences, University of Murcia, Campus of International Excellence "Campus Mare Nostrum", Campus of Espinardo, Espinardo, 30.100 Murcia, Spain.ORCID 0000-0003-2096-0167

Funding

Estrella de Levante S.A.U
6 · The paper itself

Abstract

Brewers' spent grain (BSG), which accounts for approximately 85% of the by-products generated during beer production, is a valuable source of dietary fibre, proteins and antioxidant compounds. This study aimed to characterise the chemical composition, techno-functional properties, antioxidant capacity and potential prebiotic effect of BSG flour as a sustainable functional ingredient. Dietary fibre composition, mineral content, and extractable and non-extractable (poly)phenol fractions were determined. The prebiotic potential of BSG flour was evaluated using an in vitro fermentation model with human faeces. Microbial metabolic activity was assessed through the production of short-chain fatty acids (SCFAs), lactate and ammonium, alongside changes in antioxidant capacity during fermentation, while microbiota composition was analysed by 16S rRNA amplicon sequencing. BSG flour showed high levels of insoluble fibre, mainly hemicellulose and arabinoxylans, as well as proteins and non-extractable (poly)phenols, particularly hydroxycinnamic acid derivatives. In vitro fermentation led to a significant increase in SCFA production, particularly acetate and propionate, indicating active degradation of fibre polysaccharides. These metabolic changes were accompanied by enhanced antioxidant capacity and shifts in microbiota composition, including an increased relative abundance of Bifidobacterium species. Overall, this study suggests that BSG flour could be used as a novel ingredient for the development of dietary-fibre-rich foods with potential gut health benefits.

Indexed as

brewer’s spent grainby-productsdietary fibrefunctional ingredientsgut microbiotain vitro fermentation(poly)phenolsshort-chain fatty acids

Identifiers

PMID42279718
PMCPMC13256589

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.