Garlic Polysaccharides Ameliorate AOM/DSS-Induced Colon Tumorigenesis: A Multi-Omics Mechanistic Study.

Yongqiu Qi, Xiaoming Lu, Lingyu Li, Zhenjia Zheng, Yiteng Qiao

Abstract read

In one paragraph

Article in Foods (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yongqiu QiKey Laboratory of Food Nutrition and Health in Universities of Shandong, College of Food Science and Engineering, Shandong Agricultural University, 61 Daizong Street, Tai'an 271018, China.

Xiaoming LuKey Laboratory of Food Nutrition and Health in Universities of Shandong, College of Food Science and Engineering, Shandong Agricultural University, 61 Daizong Street, Tai'an 271018, China.

Lingyu LiKey Laboratory of Food Nutrition and Health in Universities of Shandong, College of Food Science and Engineering, Shandong Agricultural University, 61 Daizong Street, Tai'an 271018, China.

Zhenjia ZhengKey Laboratory of Food Nutrition and Health in Universities of Shandong, College of Food Science and Engineering, Shandong Agricultural University, 61 Daizong Street, Tai'an 271018, China.ORCID 0000-0003-3663-6273

Yiteng QiaoKey Laboratory of Food Nutrition and Health in Universities of Shandong, College of Food Science and Engineering, Shandong Agricultural University, 61 Daizong Street, Tai'an 271018, China.

Funding

National Natural Science Foundation of China No.31801559Science and Technology Innovation Boosting Action Plan for Rural Revitalization of Shandong Province 2024TZXD007

6 · The paper itself

Abstract

As important sources of prebiotics, natural plant polysaccharides have been widely investigated owing to their excellent anti-inflammatory, anti-tumor, immunomodulatory, and gut microbiota-regulating effects. This study explored the anti-tumor effects and underlying mechanisms of garlic polysaccharides (GP-1) in a mouse model of azoxymethane/dextran sulfate sodium-induced colitis-associated colon tumorigenesis. GP-1, identified as a typical fructan (molecular weight: 3583 Da) with (2→1) and (2→6) linkages, significantly improved survival rate, reduced colon tumor burden, and alleviated intestinal bleeding in tumor mice. Furthermore, intestinal damage was significantly attenuated, as evidenced by enhanced barrier integrity, downregulated pro-inflammatory cytokines, and elevated antioxidant enzyme activities. GP-1 also inhibited aberrant epithelial proliferation by suppressing Ki67 protein expression. Multi-omics analyses revealed that these benefits might be associated with gut microbiota and metabolite remodeling, as well as transcriptional suppression of key inflammatory/tumorigenic pathways. Our findings highlighted the inhibitory effect of GP-1 on colon tumorigenesis and supported its potential as a gut-health-promoting functional food ingredient.

Indexed as

anti-inflammatoryanti-tumorcolitis-associated colon tumorigenesisgarlic polysaccharidesgut microbiotaintestinal metabolitestranscriptomics

Identifiers

PMID42279688

DOI10.3390/foods15111901

PMCPMC13256388

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.