ArticleDiagnostics (Basel, Switzerland)2026
Relapsing Polychondritis Mimicking ANCA-Negative Granulomatosis with Polyangiitis: Diagnostic Value of
Article in Diagnostics (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Relapsing polychondritis (RP) is a rare autoimmune disease of cartilaginous structures, often diagnosed late due to nonspecific presentations. Both RP and granulomatosis with polyangiitis (GPA) can cause diffuse tracheobronchial wall thickening on computed tomography (CT) and may be seronegative for anti-neutrophil cytoplasmic antibody (ANCA), creating a diagnostic impasse. We report a 46-year-old man with two months of fever, productive cough, and sternal pain. A saddle nose deformity was the only cartilaginous sign; serum ANCA was repeatedly negative. Neck CT showed diffuse tracheal and bilateral main bronchial wall thickening; the report listed amyloidosis and GPA as differential diagnoses, omitting RP. Despite laboratory, microbiological, and imaging workup, the fever fulfilled criteria for fever of unknown origin (FUO), prompting
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