Evidence map›Paper›PMID 42279471›Full record

ReviewDiagnostics (Basel, Switzerland)2026

Renal Tubular Epithelial Cells as Central Hubs of Kidney Disease.

Charlotte Delrue, Matthijs Oyaert, Eric Hoste, Joris R Delanghe, Marijn M Speeckaert

Abstract readReview
In one paragraph

Review in Diagnostics (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Charlotte DelrueDepartment of Nephrology, Ghent University Hospital, 9000 Ghent, Belgium.
Matthijs OyaertDepartment of Laboratory Medicine, Ghent University Hospital, 9000 Ghent, Belgium.
Eric HosteDepartment of Intensive Care Medicine, Ghent University Hospital, 9000 Ghent, Belgium.ORCID 0000-0001-9301-8055
Joris R DelangheDepartment of Diagnostic Sciences, Ghent University, 9000 Ghent, Belgium.ORCID 0000-0002-5702-6792
Marijn M SpeeckaertDepartment of Nephrology, Ghent University Hospital, 9000 Ghent, Belgium.ORCID 0000-0001-9183-4390

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Renal tubular epithelial cells (RTECs) are increasingly recognized as key players in kidney diseases. They integrate metabolic, inflammatory, and fibrotic signals. This article reviews new data suggesting that RTECs could function as central integrators within diagnostic networks, linking cellular stress responses to detectable blood and urine biomarkers. We discuss the latest advances in multi-omics, extracellular vesicles, and single-cell technologies that enable precise identification of RTEC states. Finally, we discuss the potential of RTEC-centric diagnostics and highlight current limitations in early disease recognition, stratification, and the development of personalized therapeutic interventions.

Indexed as

acute and chronic kidney injuryextracellular vesiclesmulti-omics diagnosticsrenal tubular epithelial cells

Identifiers

PMID42279471
PMCPMC13256752

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.