ReviewCancers2026
Pan-RAS Inhibitors: Expanding Therapeutic Potential and Evading Resistance.
Sindhu Ramesh, Junwei Wang, Chung-Hui Huang, Austin M Moore, Khalda Fadlalla, Kristy L Berry, Yulia Y Maxuitenko, Xi Chen, Adam B Keeton, Bassel El-Rayes and 5 more
Abstract readReview
In one paragraphReview in Cancers, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
15 authors.
Sindhu RameshDepartment of Drug Discovery and Development, Harrison College of Pharmacy, Auburn University, Auburn, AL 36849, USA.
Junwei WangDepartment of Drug Discovery and Development, Harrison College of Pharmacy, Auburn University, Auburn, AL 36849, USA.
Chung-Hui HuangDepartment of Drug Discovery and Development, Harrison College of Pharmacy, Auburn University, Auburn, AL 36849, USA.ORCID 0000-0003-0974-3532 Austin M MooreDepartment of Drug Discovery and Development, Harrison College of Pharmacy, Auburn University, Auburn, AL 36849, USA.ORCID 0009-0000-8591-2356 Khalda FadlallaDepartment of Drug Discovery and Development, Harrison College of Pharmacy, Auburn University, Auburn, AL 36849, USA.
Kristy L BerryDepartment of Drug Discovery and Development, Harrison College of Pharmacy, Auburn University, Auburn, AL 36849, USA.
Yulia Y MaxuitenkoDepartment of Drug Discovery and Development, Harrison College of Pharmacy, Auburn University, Auburn, AL 36849, USA.ORCID 0000-0001-5518-4941 Xi ChenDepartment of Drug Discovery and Development, Harrison College of Pharmacy, Auburn University, Auburn, AL 36849, USA.
Adam B KeetonDepartment of Drug Discovery and Development, Harrison College of Pharmacy, Auburn University, Auburn, AL 36849, USA.
Bassel El-RayesDivision of Oncology, Moores Cancer Center, University of California, San Diego, CA 92037, USA.
Gang ZhouGeorgia Cancer Center, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.ORCID 0000-0001-8967-114X Amit K MitraDepartment of Drug Discovery and Development, Harrison College of Pharmacy, Auburn University, Auburn, AL 36849, USA.ORCID 0000-0003-4046-7070 Gary A PiazzaDepartment of Drug Discovery and Development, Harrison College of Pharmacy, Auburn University, Auburn, AL 36849, USA.ORCID 0000-0003-4418-887X Funding
Exploiting the immunomodulatory effects of sulindac and novel non-COX inhibitory derivatives for cancer treatmentR01CA238514 · NCI · AUGUSTA UNIVERSITY · PI PIAZZA, GARY A, ZHOU, GANG · 2020 to 2024
$2.1MNovel inhibitor for oncogenic RAS for lung cancerR01CA254197 · NCI · AUBURN UNIVERSITY AT AUBURN · PI PIAZZA, GARY A · 2021 to 2025
$1.9MNCI NIH HHS R01CA238514NCI NIH HHS R01CA254197
6 · The paper itselfAbstract
Approximately 30% of all human cancers are driven by mutations in
Indexed as
cancerpan-KRASpan-RASRASresistancetherapeutic
Identifiers
PMID42279426
PMCPMC13257152
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390