Evidence map›Paper›PMID 42279404›Full record

ArticleCancers2026

Genetic Variability in the IGF-1 Axis Modulates Cancer-Associated Cachexia and Prognosis.

Mariana Moreira Pires, Inês Guerra de Melo, Ana Carolina Leão Silva, Virgínia Rocha Dias, Cláudia Silva, Maria Paula Silva, Joana M O Santos, Tiago Ferreira, Valéria Tavares, Rui Medeiros

Abstract read
In one paragraph

Article in Cancers, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Mariana Moreira PiresFaculty of Medicine (FMUP), University of Porto, 4200-072 Porto, Portugal.
Inês Guerra de MeloMolecular Oncology and Viral Pathology Group, IPO Porto Research Centre (CI-IPOP), Portuguese Oncology Institute of Porto (IPO Porto)/Department of Pathology and Laboratory Medicine/RISE-Associate Laboratory (Health Research Network)/Porto Comprehensive Cancer Centre Raquel Seruca (Porto.CCC), 4200-072 Porto, Portugal.
Ana Carolina Leão SilvaFaculty of Medicine (FMUP), University of Porto, 4200-072 Porto, Portugal.ORCID 0000-0002-1969-9363
Virgínia Rocha DiasDay Hospital, Portuguese Oncology Institute of Porto (IPO Porto), 4200-072 Porto, Portugal.
Cláudia SilvaDay Hospital, Portuguese Oncology Institute of Porto (IPO Porto), 4200-072 Porto, Portugal.
Maria Paula SilvaPalliative Care Service, Portuguese Oncology Institute of Porto (IPO Porto), 4200-072 Porto, Portugal.
Joana M O SantosMolecular Oncology and Viral Pathology Group, IPO Porto Research Centre (CI-IPOP), Portuguese Oncology Institute of Porto (IPO Porto)/Department of Pathology and Laboratory Medicine/RISE-Associate Laboratory (Health Research Network)/Porto Comprehensive Cancer Centre Raquel Seruca (Porto.CCC), 4200-072 Porto, Portugal.ORCID 0000-0002-6268-524X
Tiago FerreiraMolecular Oncology and Viral Pathology Group, IPO Porto Research Centre (CI-IPOP), Portuguese Oncology Institute of Porto (IPO Porto)/Department of Pathology and Laboratory Medicine/RISE-Associate Laboratory (Health Research Network)/Porto Comprehensive Cancer Centre Raquel Seruca (Porto.CCC), 4200-072 Porto, Portugal.ORCID 0000-0002-6652-9770
Valéria TavaresMolecular Oncology and Viral Pathology Group, IPO Porto Research Centre (CI-IPOP), Portuguese Oncology Institute of Porto (IPO Porto)/Department of Pathology and Laboratory Medicine/RISE-Associate Laboratory (Health Research Network)/Porto Comprehensive Cancer Centre Raquel Seruca (Porto.CCC), 4200-072 Porto, Portugal.ORCID 0000-0003-3680-7757
Rui MedeirosMolecular Oncology and Viral Pathology Group, IPO Porto Research Centre (CI-IPOP), Portuguese Oncology Institute of Porto (IPO Porto)/Department of Pathology and Laboratory Medicine/RISE-Associate Laboratory (Health Research Network)/Porto Comprehensive Cancer Centre Raquel Seruca (Porto.CCC), 4200-072 Porto, Portugal.ORCID 0000-0003-3010-8373

Funding

Centre for the Research and Technology of Agro-Environmental and Biological Sciences UIDB/04033/2025Institute for Innovation, Capacity Building and Sustainability of AgriFood Production (Inov4Agro) LA/P/0126/2020IPO Porto PI127-CI-IPOP-118-2019Portuguese League Against Cancer - Northern Branch (LPCC-NRN)
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

biomarkerscachexiaIGF-1neoplasmspolymorphism, single-nucleotide

Identifiers

PMID42279404
PMCPMC13256795

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.