ArticleCancers2026
Has Glioblastoma Five- and Ten-Year Survival Been Affected by New Treatment Algorithms in Population-Based Data? A Retrospective Swedish Survey Between 1958 and 2015.
Article in Cancers, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundGlioblastoma carries a dismal prognosis, with only a small proportion of patients surviving beyond five or ten years. Although the introduction of new oncological therapies has improved median overall survival among treated patients, their impact on long-term survival in population-based cohorts remains unclear. The primary aim of this study was to analyze temporal trends in long-term survival in Sweden.
methodsLong-term survivors with glioblastoma were analyzed in two cohorts. The first cohort comprised patients from all of Sweden identified through the Swedish Cancer Registry and the Cause of Death Registry between 1958 and 1999. The second cohort consisted of patients from Southeastern Sweden identified through the Swedish Brain Tumor Registry between 2000 and 2015.
resultsFollowing a review of the original pathology reports, the diagnosis of glioblastoma among long-term survivors was found to be incorrect in 88% and 40% of cases in the first and second cohorts, respectively. In total, 89 five-year survivors were identified, including 66 and 23 patients in the respective cohorts. Younger age (
conclusionsFive-year survival in glioblastoma increased significantly in Southeastern Sweden after 2005, possibly reflecting the impact of modern neuro-oncological treatment strategies. However, ten-year survival remained unchanged. A small subset of glioblastoma patients can nevertheless achieve very long survival and, in rare cases, complete remission.
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