ArticleCancers2026
Extracellular Matrix-Related Gene Signature Implied Immunosuppressive Status and Adverse Survival in Diffuse Glioma Patients.
Article in Cancers, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundDiffuse glioma is the most common and lethal primary malignant brain tumor, with a complicated tumor microenvironment reported. However, the role of the extracellular matrix (ECM) in diffuse gliomas remains unclear.
methodsTo investigate the impact of ECM on glioma malignancy, we constructed an ECM-related signature with six selected prognosis-related genes (VTN, VCAN, TNC, LOXL1, EFEMP1, and AGRN) using the LASSO method.
resultsThis score was found to significantly differentiate between groups classified by clinical characteristics. Despite elevated immune infiltration and antigen release, the high-ECM-score group exhibited attenuated immune activation with profound exhaustion. Moreover, the ECM score demonstrated accurate prognostic predictive power across three independent validation datasets.
conclusionsElevated ECM scores characterize an exhausted immune phenotype and are associated with a poorer prognosis in patients with diffuse glioma. This study enhances our understanding of the role of ECM in the malignant progression of gliomas.
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