Evidence map›Paper›PMID 42278845›Full record

ArticleHealthcare (Basel, Switzerland)2026

Association Between Caries Risk and Public Water Fluoridation in Balsas, Maranhão: A Cross-Sectional Study.

Laura Valentina Borges Pes, Alanna Ramalho Mateus, Haylla de Faria Horta, Adrielle Ouchi Lopes, Brenda Renata Lopes Justo, João Victor de Araújo Narciso, Mariana Gabriel, Sérgio Alves Guida Freitas Júnior, Janaílla Ribeiro Moura, Caio Sampaio and 3 more

Abstract read
In one paragraph

Article in Healthcare (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Laura Valentina Borges PesGraduate Program in Sciences, School of Dentistry, São Paulo State University (UNESP), Araçatuba 16015-050, SP, Brazil.
Alanna Ramalho MateusGraduate Program in Sciences, School of Dentistry, São Paulo State University (UNESP), Araçatuba 16015-050, SP, Brazil.ORCID 0009-0002-9727-195X
Haylla de Faria HortaGraduate Program in Sciences, School of Dentistry, São Paulo State University (UNESP), Araçatuba 16015-050, SP, Brazil.ORCID 0000-0001-6992-0217
Adrielle Ouchi LopesGraduate Program in Sciences, School of Dentistry, São Paulo State University (UNESP), Araçatuba 16015-050, SP, Brazil.ORCID 0000-0001-7667-1810
Brenda Renata Lopes JustoSchool of Dentistry, São Paulo State University (UNESP), Araçatuba 16015-050, SP, Brazil.ORCID 0009-0002-7577-5153
João Victor de Araújo NarcisoGraduate Program in Sciences, School of Dentistry, São Paulo State University (UNESP), Araçatuba 16015-050, SP, Brazil.ORCID 0009-0009-8311-3038
Mariana GabrielDepartment of Basic Sciences, School of Dentistry, São Paulo State University (UNESP), Araçatuba 16015-050, SP, Brazil.
Sérgio Alves Guida Freitas JúniorMunicipal Health Department of Balsas, Balsas 65800-000, MA, Brazil.
Janaílla Ribeiro MouraSchool of Dentistry, UNIBALSAS University Center, Balsas 65800-000, MA, Brazil.
Caio SampaioDepartment of Pediatric Dentistry and Public Health, School of Dentistry, São Paulo State University (UNESP), Araçatuba 16015-050, SP, Brazil.ORCID 0000-0002-6861-7205
Adolfo José da MotaGraduate Program in Biotechnology, Biosciences Institute, Federal University of Amazonas, Manaus 69080-900, AM, Brazil.ORCID 0000-0002-9745-1128
Wilson Galhego GarciaDepartment of Basic Sciences, School of Dentistry, São Paulo State University (UNESP), Araçatuba 16015-050, SP, Brazil.
Cristina AntonialiDepartment of Basic Sciences, School of Dentistry, São Paulo State University (UNESP), Araçatuba 16015-050, SP, Brazil.ORCID 0000-0002-0315-6161

Funding

Coordenação de Aperfeicoamento de Pessoal de Nível Superior Finance Code 001National Council for Scientific and Technological Development PIBIC - process number 177740/2024-8São Paulo State University Pro-Rectory of Extension and Culture (PROEC), proposal number 1502
6 · The paper itself

Abstract

INTRODUCTION/

objectivesDental caries is a significant public health burden in Brazil, with regional disparities deeply affecting children in the North and Northeast. This study assessed the prevalence and severity of dental caries in preschool children from Balsas (MA) and investigated its association with fluoride concentrations in the public water supply.

methodsA cross-sectional study was conducted with 256 children (aged 3-5 years) enrolled in municipal schools. Schools were selected using a stratified sampling strategy based on the water network, with exposure validated via chemical analysis. Calibrated dentists performed examinations using the FOA-UNESP risk scale, assessing biofilm and gingivitis as objective clinical proxies for hygiene. Fluoride levels were analyzed using an ion-selective electrode. Statistical analysis included Fisher's exact test, Kruskal-Wallis, and Multiple Correspondence Analysis (MCA).

resultsCaries prevalence was 60.16%, with 41.8% of children in severe risk categories (F: 27.0%; G: 14.8%). Water analysis revealed universal hypofluoridation (0.02-0.34 µg F/mL). A significant association was found between residual fluoride (0.02 µg F/mL) and greater caries severity (

conclusionsHigh caries prevalence associated with inadequate fluoridation highlights critical regional health inequalities in Balsas. These findings underscore the urgent need for policies ensuring universal water fluoridation and strengthening school-based preventive strategies to mitigate the impact of social determinants on child development.

Indexed as

childdental cariesdrinking wateroral healthpreschoolpublic healthsocial determinants of healthwater fluoridation

Identifiers

PMID42278845
PMCPMC13257183

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.