ReviewHealthcare (Basel, Switzerland)2026
Exercise for Bone Mineral Density in People with Inflammatory Bowel Disease: A Systematic Review.
Review in Healthcare (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
objectivesInflammatory bowel disease (IBD) is associated with reduced areal bone mineral density (aBMD) and an increased risk of osteoporosis and fragility fractures. Although exercise improves bone health in the general population, its effects on aBMD in adults with IBD are unclear. This systematic review aimed to evaluate the effects of structured exercise interventions on aBMD in adults with IBD and to assess the certainty of the evidence.
methodsWe conducted a systematic review in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and the Cochrane Handbook. Searches were performed in CENTRAL, MEDLINE, Scopus, and Web of Science from inception to November 2025. We included randomized controlled trials comparing structured exercise interventions with usual care, no structured exercise or no intervention in participants aged 16 years and older with IBD. The primary outcome was aBMD; physical activity was a secondary outcome. Risk of bias was assessed using the Cochrane Risk of Bias tool (RoB 2.0), and certainty of evidence was evaluated using Grading of Recommendations Assessment, Development and Evaluation (GRADE). The review protocol was registered in International Prospective Register of Systematic Reviews (PROSPERO) CRD42024617200.
resultsTwo randomized controlled trials (
conclusionsWe are very uncertain about the effect of exercise interventions on aBMD in adults with IBD. Current randomized evidence is limited to adults with Crohn's disease and is insufficient to determine the optimal exercise modality, frequency, intensity, progression, or loading characteristics for improving bone health. Well-designed trials across IBD phenotypes are needed to clarify the role of exercise in bone health management in IBD.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.