Evidence map›Paper›PMID 42278668›Full record

ArticleInternational journal of molecular sciences2026

Multi-Omics Profiling Reveals Capsaicin Suppresses EBV Lytic Reactivation in Epithelial Cancers by Targeting Viral and Host Regulatory Networks.

Nutchanat Chatchawankanpanich, Chanitchote Piyapittayanun, Chamsai Pientong, Chukkris Heawchaiyaphum

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Nutchanat ChatchawankanpanichDepartment of Biotechnology, Faculty of Science and Technology, Thammasat University, Pathumthani 12121, Thailand.
Chanitchote PiyapittayanunDepartment of Biotechnology, Faculty of Science and Technology, Thammasat University, Pathumthani 12121, Thailand.
Chamsai PientongDepartment of Microbiology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand.ORCID 0000-0003-2797-043X
Chukkris HeawchaiyaphumDepartment of Microbiology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand.

Funding

National Research Council of Thailand N42A671020
6 · The paper itself

Abstract

Epstein-Barr virus (EBV) lytic reactivation contributes to the pathogenesis of EBV-associated epithelial malignancies, including nasopharyngeal carcinoma and gastric carcinoma, highlighting the need for therapeutic strategies targeting viral reactivation. Capsaicin exhibits anticancer and antiviral activities; however, its effects on EBV lytic reactivation remain unclear. This study investigated the effects of capsaicin on EBV lytic reactivation in EBV-positive epithelial cancer models. Capsaicin significantly suppressed the expression of lytic genes, including

Indexed as

CapsaicinEpstein-Barr Virus InfectionsGene Regulatory NetworksHerpesvirus 4, HumanHost-Pathogen InteractionsVirus ActivationCell Line, TumorHumansMultiomicsProtein Interaction MapsProteomicsCapsaicincapsaicinEBVhost–virus interactionmetabolomicsproteomicsviral reactivation

Identifiers

PMID42278668
PMCPMC13258557

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.