ArticleInternational journal of molecular sciences2026
Integrated Transcriptomic Analysis Suggests a C1Q-Related Macrophage-Fibroblast Signaling Axis in Keloids.
Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Keloids are fibroproliferative scars characterized by immune dysregulation, persistent fibroblast activation, and excessive extracellular matrix deposition. The mechanisms by which macrophage functional states regulate pathological fibroblast activation remain incompletely understood. Bulk RNA-seq and single-cell RNA-seq datasets were integrated to characterize the immune-fibrotic microenvironment of keloids and infer candidate macrophage-fibroblast communication axes. Candidate findings were further assessed by tissue immunofluorescence and preliminary in vitro phenotypic evaluation using C1Q stimulation and RAP intervention in keloid fibroblasts. Bulk transcriptomic analysis revealed coordinated activation of immune-related and fibrotic remodeling programs in keloids. Single-cell analysis identified activated profibrotic fibroblast states and a macrophage population with M2-like features. Ligand-target inference nominated
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