ArticleInternational journal of molecular sciences2026
Deep Learning-Guided Reverse Translation Enhances Soluble Expression of Recombinant Proteins in
Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Enhancing the soluble expression of heterologous proteins in chassis microorganisms is critical for fundamental biological research and synthetic biology-driven industrial applications. Current methods for designing DNA sequences to ensure high soluble expression often rely excessively on high-frequency codons while overlooking optimal codon context, leading to suboptimal outcomes. To address these limitations, we developed an integrated deep learning framework combining a synonymous codon generation (SCG) model and a gene expression level prediction (GELP) model. The SCG model captures codon usage patterns in
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