Evidence map›Paper›PMID 42278597›Full record

ArticleInternational journal of molecular sciences2026

DNA Oxidation and Expression of Repair Enzymes in Organ- Cultured Human Limbal Epithelium.

Bjørn Otto Nicolaissen, Giang Nguyen, Kahsai Beraki, Amaya Azqueta, Goran Petrovski, Morten C Moe, Dag Krohn-Hansen, Andrew R Collins, Bjørn Nicolaissen, Yolanda Lorenzo

Abstract read
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In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Bjørn Otto NicolaissenDepartment of Ophthalmology, Vestre Viken Hospital Trust, 3004 Drammen, Norway.
Giang NguyenFaculty of Medicine, University of Oslo, 0372 Oslo, Norway.
Kahsai BerakiCenter for Eye Research and Innovative Diagnostics, Department of Ophthalmology, Oslo University Hospital, 0450 Oslo, Norway.
Amaya AzquetaDepartment of Pharmaceutical Science, School of Pharmacy and Nutrition, University of Navarra, 31008 Pamplona, Spain.ORCID 0000-0003-4857-9931
Goran PetrovskiCenter for Eye Research and Innovative Diagnostics, Department of Ophthalmology, Oslo University Hospital, 0450 Oslo, Norway.ORCID 0000-0003-2905-9252
Morten C MoeCenter for Eye Research and Innovative Diagnostics, Department of Ophthalmology, Oslo University Hospital, 0450 Oslo, Norway.
Dag Krohn-HansenCenter for Eye Research and Innovative Diagnostics, Department of Ophthalmology, Oslo University Hospital, 0450 Oslo, Norway.
Andrew R CollinsDepartment of Nutrition, Institute of Basic Medical Sciences, University of Oslo, 0372 Oslo, Norway.ORCID 0000-0001-5916-6871
Bjørn NicolaissenCenter for Eye Research and Innovative Diagnostics, Department of Ophthalmology, Oslo University Hospital, 0450 Oslo, Norway.
Yolanda LorenzoCenter for Eye Research and Innovative Diagnostics, Department of Ophthalmology, Oslo University Hospital, 0450 Oslo, Norway.

Funding

Arthur and Clauson's legacy No grant numberBlindemission IL No grant numberCenter for eye research and innovative Diagnostics No grant numberInger Holms Memorial Fund No grant numberOslo University Hospital No grant numberThe Norwegian Association of The Blind and Partially Sighted No grant numberUniversity of Oslo No grant number
6 · The paper itself

Abstract

DNA oxidation damage and its repair are essential for maintaining genomic integrity in the human limbal epithelium, which harbors corneal epithelial stem cells. This study investigated the distribution of the DNA base oxidation 8-oxoguanine (8-oxoG) and the base excision repair (BER) enzymes 8-oxoguanine DNA glycosylase (OGG1) and apurinic/apyrimidinic endonuclease 1 (APE1) in non-cultured and eye-bank organ-cultured human limbal epithelia. Immunohistochemistry was used to assess the localization and staining intensity of 8-oxoG, OGG1, and APE1, evaluated semi-quantitatively and by image analysis. In situ hybridization was performed to detect the distribution of

Indexed as

DNADNA-(Apurinic or Apyrimidinic Site) LyaseDNA GlycosylasesDNA RepairEpithelium, CornealLimbus CorneaeAdultAgedDNA DamageExcision RepairFemaleGuanineHumansMaleMiddle AgedOrgan Culture Techniques8-hydroxyguanineAPEX1 protein, humanDNADNA-(Apurinic or Apyrimidinic Site) LyaseDNA GlycosylasesGuanineoxoguanine glycosylase 1, human8-oxoGAPE1DNA oxidation damagehuman limbal epitheliumOGG1repair enzymes

Identifiers

PMID42278597
PMCPMC13257039

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.