ArticleInternational journal of molecular sciences2026
TRPV4-Dependent Epithelial Mechanoadaptation and Barrier Remodeling Mediate Sennoside-Induced Distal Colonic Motility.
Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Improvement of bowel function is accompanied by increased luminal flow and altered epithelial mechanical forces, yet the underlying epithelial mechanisms remain unclear. We investigated whether enhanced luminal stimulation is associated with epithelial mechanotransduction and junctional remodeling during changes in colonic motility. Sennoside was orally administered at 4.8 mg/kg body weight to 5-week-old male BALB/cAJcl mice for 21 days to model increased luminal stimulation. Stool characteristics, fecal water content, Bristol Stool Form Scale scores, and segmental colonic motility were assessed. Expression of Muc2, inflammatory cytokines, Trpv4, and E-cadherin was quantified across colonic regions. In CT26 monolayers, mechanical stress was applied to evaluate transient receptor potential channel induction, E-cadherin redistribution, and transepithelial electrical resistance, and the effect of
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