Evidence map›Paper›PMID 42278577›Full record

ArticleInternational journal of molecular sciences2026

Characterization of the Effect of α-Lipoic Acid in Human Macrophages Infected with

Alessandro Salustri, Gioia Cappelletti, Flavio De Maio, Youqing Shen, Filomena Nuzzi, Ivana Palucci, Francesco Paglione, Maurizio Sanguinetti, Michela Sali, Giovanni Delogu

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Alessandro SalustriDepartment of Basic Biotechnological Sciences, Clinical, Intensive and Perioperative, Section of Microbiology, Catholic University of Sacred Heart, Largo Francesco Vito 1, 00168 Rome, Italy.ORCID 0000-0002-8615-7265
Gioia CappellettiDepartment of Basic Biotechnological Sciences, Clinical, Intensive and Perioperative, Section of Microbiology, Catholic University of Sacred Heart, Largo Francesco Vito 1, 00168 Rome, Italy.ORCID 0000-0002-2932-2391
Flavio De MaioDepartment of Laboratory and Hematologic Sciences, Fondazione Policlinico Universitario A. Gemelli IRCCS, Largo Agostino Gemelli 8, 00168 Rome, Italy.ORCID 0000-0002-4744-9820
Youqing ShenZhejiang Key Laboratory of Smart Biomaterials, Center for Bionanoengineering, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310058, China.
Filomena NuzziDepartment of Basic Biotechnological Sciences, Clinical, Intensive and Perioperative, Section of Microbiology, Catholic University of Sacred Heart, Largo Francesco Vito 1, 00168 Rome, Italy.
Ivana PalucciDepartment of Basic Biotechnological Sciences, Clinical, Intensive and Perioperative, Section of Microbiology, Catholic University of Sacred Heart, Largo Francesco Vito 1, 00168 Rome, Italy.ORCID 0000-0003-2106-1761
Francesco PaglioneDepartment of Basic Biotechnological Sciences, Clinical, Intensive and Perioperative, Section of Microbiology, Catholic University of Sacred Heart, Largo Francesco Vito 1, 00168 Rome, Italy.
Maurizio SanguinettiDepartment of Basic Biotechnological Sciences, Clinical, Intensive and Perioperative, Section of Microbiology, Catholic University of Sacred Heart, Largo Francesco Vito 1, 00168 Rome, Italy.ORCID 0000-0002-9780-7059
Michela SaliDepartment of Basic Biotechnological Sciences, Clinical, Intensive and Perioperative, Section of Microbiology, Catholic University of Sacred Heart, Largo Francesco Vito 1, 00168 Rome, Italy.ORCID 0000-0003-3609-2990
Giovanni DeloguDepartment of Medicine and Surgery, Università degli Studi di Parma, Via Gramsci 14, 43126 Parma, Italy.

Funding

EU- MUR PNRR Extended Partnership initiative on Emerging Infectious Diseases PE00000007, INF-ACT
6 · The paper itself

Abstract

Tuberculosis (TB) treatment is severely hampered by the rise in multi-drug-resistant strains and the prevalence of drug-induced toxicities. Host-Directed Therapies (HDTs) have emerged as a promising strategy to overcome these challenges by modulating innate immunity and circumventing

Indexed as

MacrophagesMycobacterium tuberculosisThioctic AcidTuberculosisAntitubercular AgentsApoptosisHost-Directed TherapyHumansPhagosomesTHP-1 CellsAntitubercular AgentsThioctic Acidhost-directed therapiesphagosome acidificationTHP-1 macrophagestuberculosisα-lipoic acid

Identifiers

PMID42278577
PMCPMC13256351

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.