An Exploratory Study of High-Concentration Trace Amine Effects and Adrenoceptor Expression Patterns in SH-SY5Y Cells and Neuroblastoma.

Aleksandr V Lopachev, Rogneda B Kazanskaya, Raul R Gainetdinov, Evgeny V Kanov, Anastasia N Vaganova

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Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

5 authors.

Aleksandr V LopachevInstitute of Translational Biomedicine, St. Petersburg State University, Universitetskaya Embankment. 7/9, 199034 St. Petersburg, Russia.ORCID 0000-0002-5688-3899

Rogneda B KazanskayaInstitute of Translational Biomedicine, St. Petersburg State University, Universitetskaya Embankment. 7/9, 199034 St. Petersburg, Russia.ORCID 0000-0002-2194-6749

Raul R GainetdinovInstitute of Translational Biomedicine, St. Petersburg State University, Universitetskaya Embankment. 7/9, 199034 St. Petersburg, Russia.

Evgeny V KanovInstitute of Translational Biomedicine, St. Petersburg State University, Universitetskaya Embankment. 7/9, 199034 St. Petersburg, Russia.ORCID 0000-0002-3315-6170

Anastasia N VaganovaInstitute of Translational Biomedicine, St. Petersburg State University, Universitetskaya Embankment. 7/9, 199034 St. Petersburg, Russia.ORCID 0000-0002-0101-1065

Funding

St Petersburg University 148723091

6 · The paper itself

Abstract

The antitumoral activity of monoamine receptor ligands appears to be important as a potential approach to cancer medication. In the present study, we evaluated the effects of trace amine compounds, including octopamine, tyramine, 3-methoxytyramine, and synephrine, on SH-SY5Y neuroblastoma cells. Previously, these compounds exhibited TAAR1-specific activity at nanomolar concentrations. However, in SH-SY5Y neuroblastoma cells, the effect of octopamine and 3-methoxytyramine was identified in concentrations of 1000 µM or above and is apparently non-specific. Neither public transcriptomic datasets nor qPCR analysis detected significant

Indexed as

AminesGene Expression Regulation, NeoplasticNeuroblastomaReceptors, AdrenergicCell Line, TumorGene Expression ProfilingHumansTrace Amine-Associated ReceptorsTranscriptomeAminesReceptors, AdrenergicTrace Amine-Associated ReceptorsadrenoceptorsdopamineGPCRmonoaminesneuroblastomatrace amines

Identifiers

PMID42278562

DOI10.3390/ijms27115038

PMCPMC13256704

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LicenceCC BY

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.