ArticleInternational journal of molecular sciences2026
Do Biochemical Markers Reflect Parathyroid Adenoma Volume in Primary Hyperparathyroidism?
Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The relationship between biochemical severity parameters and adenoma burden in primary hyperparathyroidism (PHPT) has been widely studied, although some variability across studies persists. This relationship is clinically relevant for improving disease assessment and guiding surgical decision-making. This study aimed to investigate the association between preoperative biochemical parameters and both ultrasonographic and histopathological adenoma volume. A total of 526 patients with histopathologically confirmed solitary parathyroid adenoma who underwent surgery between January 2017 and December 2024 were retrospectively analyzed. Preoperative corrected serum calcium, parathyroid hormone (PTH), 25-OH vitamin D, phosphorus, albumin, and alkaline phosphatase (ALP) levels were recorded. Adenoma volume was calculated using ultrasonographic measurements and histopathological dimensions, and correlations were evaluated with appropriate statistical methods. Corrected serum calcium showed a significant positive correlation with histopathological adenoma volume (r = 0.249,
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