ArticleInternational journal of molecular sciences2026
Circulating Adipsin as a Biomarker of Liver Fat Content in Prepubertal Children Born Small-for-Gestational-Age.
Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Adipsin is a serine protease secreted mainly by adipocytes with a key role in the regulation of lipid metabolism and energy homeostasis. Individuals born small-for-gestational-age (SGA) with excessive postnatal catch-up in weight are at risk of developing central (hepato-visceral) fat deposition and features of metabolic dysfunction-associated steatotic liver disease (MASLD). We assessed cross-sectionally the serum concentrations of adipsin in seventy-five prepubertal children, aged ~7.8 yr, born appropriate-for-gestational-age (AGA, N = 40) or SGA (with spontaneous catch-up, N = 35) and their association with markers of abdominal adiposity and metabolic health. Assessments included anthropometry, serum adipsin, glucose, insulin, high-molecular-weight adiponectin (HMW-adip), lipids, and abdominal fat partitioning by magnetic resonance imaging (MRI). SGA children had higher serum adipsin levels [1.9 mg/L ± 0.4 vs. 1.4 mg/L ± 0.1 (mean ± SEM);
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