Evidence map›Paper›PMID 42278543›Full record

ArticleInternational journal of molecular sciences2026

Murine Model of Radiation Dermatitis with Experimental Wound and Effects of Genistein.

Ernest O N Phillips, Amal Alzahrani, W Bradley Rittase, John E Slaven, Donald C Aduba, Sandhya Xavier, Ji-An Wang, Evelyn C Hays, Duane Craig, Georgia E Streett and 5 more

Abstract read
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In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Ernest O N PhillipsDepartment of Medicine, Division of Dermatology USUHS, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.ORCID 0000-0003-3901-7953
Amal AlzahraniDepartment of Pharmacology and Molecular Therapeutics, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Rd., Bethesda, MD 20814, USA.
W Bradley RittaseDepartment of Pharmacology and Molecular Therapeutics, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Rd., Bethesda, MD 20814, USA.
John E SlavenDepartment of Pharmacology and Molecular Therapeutics, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Rd., Bethesda, MD 20814, USA.
Donald C AdubaDepartment of Medicine, Division of Dermatology USUHS, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.ORCID 0000-0002-0308-0064
Sandhya XavierDepartment of Medicine, Division of Dermatology USUHS, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.ORCID 0000-0003-1283-8962
Ji-An WangDepartment of Medicine, Division of Dermatology USUHS, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.
Evelyn C HaysDepartment of Pharmacology and Molecular Therapeutics, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Rd., Bethesda, MD 20814, USA.
Duane CraigDepartment of Pharmacology and Molecular Therapeutics, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Rd., Bethesda, MD 20814, USA.
Georgia E StreettDepartment of Pharmacology and Molecular Therapeutics, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Rd., Bethesda, MD 20814, USA.
Leonard SperlingDepartment of Medicine, Division of Dermatology USUHS, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.ORCID 0000-0003-2587-8023
Sang-Ho LeePathology Department, Research Services, Naval Medical Research Command, Silver Spring, MD 20910, USA.
Helena B PasiekaDepartment of Medicine, Division of Dermatology USUHS, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.ORCID 0000-0001-8446-4715
Thomas N DarlingDepartment of Medicine, Division of Dermatology USUHS, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.ORCID 0000-0002-5161-1974
Regina M DayDepartment of Pharmacology and Molecular Therapeutics, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Rd., Bethesda, MD 20814, USA.ORCID 0000-0003-0822-8993

Funding

United States Department of Defense DER-84-1174
6 · The paper itself

Abstract

Cutaneous Radiation Injuries (CRIs) and wounds within an area of radiation exposure (combined injury, CI) are a significant concern for nuclear accidents and radiation combat/terrorist events. CRIs and CI present unique clinical challenges, and effective countermeasures are urgently needed. Here we describe a murine model of CRI and CI in C57BL/6 mice using 16.9 Gy thoracic X-ray irradiation (5.3 Gy/min, 160 kV) ± experimental wound administered immediately. Wound repair and radiation-induced dermatitis were assessed after irradiation. Our previous studies showed that genistein (200 mg/kg, s.c.), administered 24 h prior to irradiation prevented radiation injuries in two murine models. We investigated the effects of genistein in the CI model. Macroscopic and histological analyses showed that radiation significantly delayed wound closure, although wounds did not significantly alter the progression of radiation dermatitis. Genistein improved the early rate of wound closure and significantly reduced dermatitis in mice. Histological analysis showed that genistein improved skin structure and reduced inflammation and fibrosis. Immunohistochemistry showed that genistein attenuated radiation-induced cyclin-dependent kinase inhibitor 1 (p21/waf1) and α-smooth muscle actin and preserved K15 positive skin adult stem cells. These findings suggest that genistein may be an effective prophylactic against CRIs and CI.

Indexed as

GenisteinRadiation Injuries, ExperimentalRadiodermatitisWound HealingActinsAnimalsCyclin-Dependent Kinase Inhibitor p21Disease Models, AnimalMaleMiceMice, Inbred C57BLSkinActinsCyclin-Dependent Kinase Inhibitor p21Genisteinaccelerated senescencedermatitisgenisteinhair follicle stem cellsionizing radiationp21/waf1

Identifiers

PMID42278543
PMCPMC13257261

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.