ArticleInternational journal of molecular sciences2026
Cucurbitacin B Promotes Tumor Necrosis Factor Receptor 1 Ectodomain Shedding by Selectively Activating the Extracellular Signal-Regulated Kinase Signaling Pathway.
Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Alantolactone Activates the Extracellular Signal-Regulated Kinase Signaling Pathway to Promote Tumor Necrosis Factor Receptor 1 Ectodomain Shedding.Molecules (Basel, Switzerland) · 2026Article
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Authors and funding
7 authors.
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Abstract
Cucurbitacin B belongs to a group of tetracyclic triterpenoids and exerts a number of biological effects, including anti-inflammatory and anticancer activities. We previously demonstrated that cucurbitacin B down-regulated tumor necrosis factor (TNF) receptor 1 (TNF-R1) expression and prevented activation of the transcription factor nuclear factor κB in response to a TNF-α stimulation. The present study shows that cucurbitacin B promoted the ectodomain shedding of TNF-R1 by generating a soluble form that accumulated in the culture medium of human lung adenocarcinoma A549 cells. Of the eight tetracyclic and pentacyclic triterpenoids consisting of an
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