Evidence map›Paper›PMID 42278528›Full record

ArticleInternational journal of molecular sciences2026

Clinicopathological Significance of Epithelial-Mesenchymal Transition in Oral Squamous Cell Carcinoma.

Paloma Lequerica-Fernández, Carmen Vallina-Fernández-Kelly, Juan Pablo Rodrigo, Rosa María López-Pintor, Héctor E Torres-Rivas, Tania Rodríguez-Santamarta, Verónica Blanco-Lorenzo, Saúl Álvarez Teijeiro, Juana M García-Pedrero, Juan Carlos de Vicente

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Paloma Lequerica-FernándezInstituto de Investigación Sanitaria del Principado de Asturias (ISPA), Instituto Universitario de Oncología del Principado de Asturias (IUOPA), Universidad de Oviedo, C/Carretera de Rubín, s/n, 33011 Oviedo, Asturias, Spain.
Carmen Vallina-Fernández-KellyDepartment of Oral and Maxillofacial Surgery, Hospital Universitario Central de Asturias (HUCA), C/Carretera de Rubín, s/n, 33011 Oviedo, Asturias, Spain.
Juan Pablo RodrigoInstituto de Investigación Sanitaria del Principado de Asturias (ISPA), Instituto Universitario de Oncología del Principado de Asturias (IUOPA), Universidad de Oviedo, C/Carretera de Rubín, s/n, 33011 Oviedo, Asturias, Spain.ORCID 0000-0003-3063-0890
Rosa María López-PintorORALMED Research Group, Department of Dental Clinical Specialties, School of Dentistry, Complutense University of Madrid, 28040 Madrid, Spain.ORCID 0000-0002-5727-0920
Héctor E Torres-RivasDepartment of Pathology, Hospital Universitario Central de Asturias (HUCA), C/Carretera de Rubín, s/n, 33011 Oviedo, Asturias, Spain.ORCID 0000-0003-0154-5240
Tania Rodríguez-SantamartaInstituto de Investigación Sanitaria del Principado de Asturias (ISPA), Instituto Universitario de Oncología del Principado de Asturias (IUOPA), Universidad de Oviedo, C/Carretera de Rubín, s/n, 33011 Oviedo, Asturias, Spain.ORCID 0000-0002-3721-119X
Verónica Blanco-LorenzoInstituto de Investigación Sanitaria del Principado de Asturias (ISPA), Instituto Universitario de Oncología del Principado de Asturias (IUOPA), Universidad de Oviedo, C/Carretera de Rubín, s/n, 33011 Oviedo, Asturias, Spain.
Saúl Álvarez TeijeiroInstituto de Investigación Sanitaria del Principado de Asturias (ISPA), Instituto Universitario de Oncología del Principado de Asturias (IUOPA), Universidad de Oviedo, C/Carretera de Rubín, s/n, 33011 Oviedo, Asturias, Spain.ORCID 0000-0002-6845-2789
Juana M García-PedreroInstituto de Investigación Sanitaria del Principado de Asturias (ISPA), Instituto Universitario de Oncología del Principado de Asturias (IUOPA), Universidad de Oviedo, C/Carretera de Rubín, s/n, 33011 Oviedo, Asturias, Spain.ORCID 0000-0002-5891-9488
Juan Carlos de VicenteInstituto de Investigación Sanitaria del Principado de Asturias (ISPA), Instituto Universitario de Oncología del Principado de Asturias (IUOPA), Universidad de Oviedo, C/Carretera de Rubín, s/n, 33011 Oviedo, Asturias, Spain.ORCID 0000-0002-0991-9465

Funding

Instituto de Salud Carlos III PI19/00560Instituto de Salud Carlos III PI19/01255Instituto de Salud Carlos III PI24/01530
6 · The paper itself

Abstract

Epithelial-mesenchymal transition (EMT) contributes to oral squamous cell carcinoma (OSCC) progression, although the clinical relevance of EMT-related markers remains controversial. This study evaluated the expression of EMT markers and transcription factors and their associations with clinicopathological features and survival in OSCC. Immunohistochemical expression of E-cadherin, N-cadherin, vimentin, and EMT-associated transcription factors (Snail1, Slug, Twist, ZEB1, ZEB2, and E47) was assessed in OSCC samples. Associations with clinicopathological variables were analyzed using χ

Indexed as

Carcinoma, Squamous CellEpithelial-Mesenchymal TransitionMouth NeoplasmsAdultAgedBiomarkers, TumorCadherinsFemaleHumansMaleMiddle AgedPrognosisTranscription FactorsVimentinBiomarkers, TumorCadherinsTranscription FactorsVimentincadherin switchingepithelial–mesenchymal transitionslugsnailvimentin

Identifiers

PMID42278528
PMCPMC13256631

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.