Evidence map›Paper›PMID 42278526›Full record

ArticleInternational journal of molecular sciences2026

Subthreshold Thermal Stress Aggravates Methamphetamine-Induced Cardiomyocyte Pyroptosis via the Mitochondrial ROS/BAX/mtDNA/NLRP3 Pathway.

Mengmeng Wang, Congcong Hou, Menglian Hu, Dan Zhou, Xintao Wang, Mingyang Jin, Chunling Ma, Jianhong Shi, Zhiyu Ni

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mengmeng WangClinical Medical College, Hebei University, Baoding 071000, China.
Congcong HouCollege of Forensic Medicine, Hebei Medical University, Shijiazhuang 050017, China.
Menglian HuCollege of Forensic Medicine, Hebei Medical University, Shijiazhuang 050017, China.
Dan ZhouCollege of Forensic Medicine, Hebei Medical University, Shijiazhuang 050017, China.
Xintao WangCollege of Forensic Medicine, Hebei Medical University, Shijiazhuang 050017, China.ORCID 0000-0002-6004-1547
Mingyang JinCollege of Forensic Medicine, Hebei Medical University, Shijiazhuang 050017, China.
Chunling MaCollege of Forensic Medicine, Hebei Medical University, Shijiazhuang 050017, China.
Jianhong ShiClinical Medical College, Hebei University, Baoding 071000, China.ORCID 0000-0003-2232-1000
Zhiyu NiClinical Medical College, Hebei University, Baoding 071000, China.

Funding

S&T Program of Baoding 2463P025the Central Government Guided Local Science and Technology Development Fund Project 236Z7744Gthe Post-graduate's Innovation Fund Project of Hebei Province, China CXZZBS2024012
6 · The paper itself

Abstract

Methamphetamine (METH)-induced cardiomyocyte injury is the leading cause of mortality beyond acute intoxication. METH abuse often occurs in crowded, poorly ventilated environments, and even moderately high ambient temperatures exacerbate METH-related cardiovascular emergencies. However, the underlying mechanisms by which environmental factors drive the progression of cardiac diseases remain poorly understood. This study modeled the real-world scenario in vivo by exposing mice to METH under normothermic condition (NC, 22 °C) or subthreshold thermal stress (STS, 28 °C, a mild thermal challenge for mice) conditions, and in vitro by using H9c2 cardiomyocytes exposed to METH at 37 °C or 39 °C. STS significantly potentiated METH-induced cardiac dysfunction, mitochondrial ultrastructural damage, and oxidative stress (

Indexed as

MethamphetamineMyocytes, CardiacNLR Family, Pyrin Domain-Containing 3 ProteinPyroptosisReactive Oxygen SpeciesAnimalsbcl-2-Associated X ProteinCell LineDNA, MitochondrialMaleMiceMice, Inbred C57BLMitochondriaOxidative StressSignal Transductionbcl-2-Associated X ProteinDNA, MitochondrialMethamphetamineNLR Family, Pyrin Domain-Containing 3 ProteinNlrp3 protein, mouseReactive Oxygen SpeciesBCL2-associated Xcardiomyocyte pyroptosismethamphetaminemitochondrial DNAmitochondria-targeted antioxidantmitoquinonereactive oxygen speciessubthreshold thermal stress

Identifiers

PMID42278526
PMCPMC13256843

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.