Evidence map›Paper›PMID 42278523›Full record

ArticleInternational journal of molecular sciences2026

Metabolic Dysregulation, Inflammation, and Median Nerve Dysfunction in Patients with Type 2 Diabetes Mellitus with Carpal Tunnel Syndrome.

Adina Stoian, Simona Cernea, Claudia Bănescu, Mircea Stoian, Andrei Manea, Florina Gliga, Dumitru Golban, Andrei Stîngaciu, Rodica Bălașa

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Adina StoianDepartment of Pathophysiology, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Târgu Mureș, Gheorghe Marinescu Street No. 38, 540142 Târgu Mureș, Romania.ORCID 0000-0001-6862-4926
Simona CerneaDepartment M3/Internal Medicine I, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Târgu Mureş, 540142 Târgu Mureş, Romania.
Claudia BănescuGenetics Department, Center for Advanced Medical and Pharmaceutical Research, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Târgu Mureș, Gheorghe Marinescu Street No. 38, 540136 Târgu Mureș, Romania.ORCID 0000-0002-3235-524X
Mircea StoianDepartment of Anesthesiology and Intensive Care Medicine, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Târgu Mureș, 540103 Târgu Mureș, Romania.ORCID 0009-0007-6297-0378
Andrei ManeaDoctoral School of Medicine and Pharmacy, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Târgu Mureș, Gheorghe Marinescu Street No. 38, 540142 Târgu Mureș, Romania.ORCID 0009-0002-0922-8565
Florina GligaDepartment of Pathophysiology, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Târgu Mureș, Gheorghe Marinescu Street No. 38, 540142 Târgu Mureș, Romania.ORCID 0000-0002-0356-822X
Dumitru Golban1st Neurology Clinic, Mureș County Clinical Emergency Hospital, 540136 Târgu Mureș, Romania.
Andrei StîngaciuIntensive Care Unit, Mures Clinical County Hospital, Street Gheorghe Marinescu No. 1, 540136 Târgu Mureș, Romania.ORCID 0009-0008-4873-8561
Rodica Bălașa1st Neurology Clinic, Mureș County Clinical Emergency Hospital, 540136 Târgu Mureș, Romania.

Funding

Universitatea de Medicină, Farmacie, Științe și Tehnologie "George Emil Palade" din Târgu Mureș 163/8/10.01.2023
6 · The paper itself

Abstract

Carpal tunnel syndrome (CTS) is the most common compressive mononeuropathy. In patients with type 2 diabetes mellitus (T2DM), chronic hyperglycemia, microangiopathy, and systemic inflammation increase the vulnerability of peripheral nerves to compression. This study aimed to assess the relationship between CTS severity and clinical, metabolic, inflammatory, and electrophysiological parameters in patients with T2DM. A cross-sectional study was conducted from June 2023 to June 2024, involving patients diagnosed with T2DM. Electrophysiological assessment of the upper and lower limbs was performed using a four-channel electromyography apparatus. Clinical and anthropometric data and laboratory parameters were obtained, as well as the results of nerve conduction studies (NCS). One hundred and twenty-three patients with T2DM were included in the study. The prevalence of moderate-to-severe forms of CTS was 43.9%, and bilateral involvement was present in 21.95% of patients. Patients with moderate-to-severe CTS had significantly higher hemoglobin A1c (HbA1c) (

Indexed as

Carpal Tunnel SyndromeDiabetes Mellitus, Type 2InflammationMedian NerveAgedCross-Sectional StudiesDiabetic NeuropathiesFemaleGlycated HemoglobinHumansMaleMiddle AgedNerve Conduction StudiesGlycated Hemoglobincarpal tunnel syndromechronic inflammationmonocytesnerve conduction studiestype 2 diabetes mellitus

Identifiers

PMID42278523
PMCPMC13256965

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.