ArticleInternational journal of molecular sciences2026
Peripartum-Associated Heart Failure Develops Independently of RHOT Proteins.
Natali Froese, Eluiesa Sina, Paolo Galuppo, Christopher Werlein, Anna Gigina, Jan Hegermann, Robert Geffers, Tim Scholz, Jan C Kamp, Lavinia Neubert and 5 more
Abstract read
In one paragraphArticle in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
15 authors.
Natali FroeseDepartment of Cardiology and Angiology, Hannover Medical School, 30625 Hannover, Germany.
Eluiesa SinaDepartment of Cardiology and Angiology, Hannover Medical School, 30625 Hannover, Germany.
Paolo GaluppoDepartment of Cardiology and Angiology, Hannover Medical School, 30625 Hannover, Germany.
Anna GiginaDepartment of Cardiology and Angiology, Hannover Medical School, 30625 Hannover, Germany.
Jan HegermannResearch Core Unit Electron Microscopy, Institute of Functional and Applied Anatomy, Hannover Medical School, 30625 Hannover, Germany.
Robert GeffersResearch Group Genome Analytics, Helmholtz Center for Infection Research, 38124 Braunschweig, Germany.ORCID 0000-0003-4409-016X Tim ScholzInstitute of Molecular and Cell Physiology, Hannover Medical School, 30625 Hannover, Germany.ORCID 0000-0002-2127-9843 Jan C KampDepartment of Respiratory Medicine and Infectious Diseases, Hannover Medical School, 30625 Hannover, Germany.ORCID 0000-0002-5002-409X Lavinia NeubertInstitute of Pathology, Hannover Medical School, 30625 Hannover, Germany.
Johanna SchneiderDepartment of Medicine IV, Medical Center-University of Freiburg, 79106 Freiburg, Germany.
Melanie Ricke-HochDepartment of Cardiology and Angiology, Hannover Medical School, 30625 Hannover, Germany.ORCID 0000-0001-5479-2275 Alexander DietlDepartment of Internal Medicine II, University Hospital Regensburg, 93053 Regensburg, Germany.ORCID 0000-0002-4091-8620 Johann BauersachsDepartment of Cardiology and Angiology, Hannover Medical School, 30625 Hannover, Germany.
Christian RiehleDepartment of Cardiology and Angiology, Hannover Medical School, 30625 Hannover, Germany.ORCID 0000-0002-0040-4254 Funding
German Research Foundation RI 2417/6-1
6 · The paper itselfAbstract
Pregnancy-associated hemodynamic overload and hormonal changes induce hypertrophy and metabolic remodeling of the maternal heart. Mitochondrial motility, mediated by ras homolog family member T (RHOT) 1 and RHOT2, is essential for cardiac adaptation to increased workload, cardiomyocyte hypertrophy, and sarcomere maturation. To test the hypothesis that
Indexed as
Heart FailurePeripartum Cardiomyopathyrho GTP-Binding ProteinsAnimalsFemaleMetabolic ReprogrammingMiceMice, KnockoutMitochondria, HeartMyocytes, CardiacPeripartum PeriodPregnancyrho GTP-Binding Proteinsheart failurehypertrophymitochondriamitochondrial motilityperipartum cardiomyopathy (PPCM)
Identifiers
PMID42278517
PMCPMC13256580
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