Evidence map›Paper›PMID 42278484›Full record

SynthesisInternational journal of molecular sciences2026

The Hidden Link Between Intestinal Helminthiasis, Gut Microbiome Alterations, and Colorectal Cancer Risk: A Systematic Review.

Dieketseng Palesa Shemfe, Nontobeko Eunice Mvubu, Pragalathan Naidoo, Jennifer Giandhari, Doratha Armen Byrd, Sayed Shakeel Kader, Zilungile Lynette Mkhize-Kwitshana

Abstract readSystematic Review
In one paragraph

Synthesis in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Dieketseng Palesa ShemfeDepartment of Medical Microbiology, School of Medicine, College of Health Sciences, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban 4001, South Africa.ORCID 0000-0003-2986-5684
Nontobeko Eunice MvubuDepartment of Medical Microbiology, School of Medicine, College of Health Sciences, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban 4001, South Africa.ORCID 0000-0002-3759-7141
Pragalathan NaidooDepartment of Medical Microbiology, School of Medicine, College of Health Sciences, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban 4001, South Africa.ORCID 0000-0002-8905-5926
Jennifer GiandhariKwaZulu-Natal Research Innovation and Sequencing Platform, School of Medicine, College of Health Sciences, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban 4001, South Africa.
Doratha Armen ByrdDepartment of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33606, USA.
Sayed Shakeel KaderDepartment of Surgery, University of KwaZulu-Natal, Durban 4001, South Africa.ORCID 0000-0002-6216-5703
Zilungile Lynette Mkhize-KwitshanaDepartment of Medical Microbiology, School of Medicine, College of Health Sciences, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban 4001, South Africa.ORCID 0000-0002-0373-9973

Funding

National Research Foundation PMDS22070734338South African Medical Research Council HDID5149/KR/202
6 · The paper itself

Abstract

Colorectal cancer (CRC) is an increasing health concern in low- and middle-income countries (LMICs), especially in Africa, driven by dietary shifts, urbanisation, infections, and limited treatment access. The gut microbiome plays a central role in CRC, while soil-transmitted helminths (STHs) exert complex effects that can promote or mitigate risk depending on species, infection intensity, and host context. This systematic review synthesised 17 human studies (2000-2026) examining helminth impacts on gut microbial diversity, revealing a dualistic pattern. Several studies reported that chronic or moderate helminth infections, such as

Indexed as

Colorectal NeoplasmsGastrointestinal MicrobiomeHelminthiasisIntestinal Diseases, ParasiticAnimalsBacteriaDysbiosisHelminthsHumansRisk Factorscolorectal cancerdysbiosisgut microbiotahelminthiasisinflammationmicrobial diversityneglected tropical diseasesoil-transmitted helminths

Identifiers

PMID42278484
PMCPMC13257214

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.