ArticleInternational journal of molecular sciences2026
Serofast Syphilis Is Associated with Phospholipid-Dependent Coagulation Abnormalities and B-Cell Activation Following Treatment.
Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
A substantial proportion of patients treated for early syphilis fail to achieve the expected ≥4-fold decline in non-treponemal titers despite appropriate therapy. This serofast state remains a common clinical dilemma, and repeated antibiotic therapy is often ineffective. We hypothesized that persistent seroreactivity may reflect infection-associated immune dysregulation rather than ongoing infection. In this prospective study, 36 adults with early syphilis were treated with benzathine penicillin. At 6 months, 11 patients with inadequate serological response underwent cerebrospinal fluid evaluation; 3 with neurosyphilis were excluded. The remaining 33 patients were classified as serofast (n = 8) or serologically cured (n = 25). Eleven healthy individuals served as controls. Serofast patients demonstrated prolonged phospholipid-dependent coagulation assays compared with serologically cured individuals (all q
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