ArticleInternational journal of molecular sciences2026
Candidate Cyanide Resistance Genes in Eutardigrade (Tardigrada) Genomes and KCN Resistance of
Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Several eutardigrade species can withstand high doses of potassium cyanide (KCN), a potent inhibitor of mitochondrial respiration, suggesting defense mechanisms that remain poorly understood. We surveyed the available tardigrade genomes in search for 11 protein families associated with cyanide detoxification and resistance in other organisms. We identified 28 sequences putatively encoding mitochondrial alternative oxidase (AOX), as well as proteins from the nitrilase superfamily and rhodanese superfamily in three eutardigrades, but found no evidence for other canonical cyanide-detoxifying enzymes such as β-cyanoalanine synthase. We also experimentally tested KCN resistance of the model tardigrade species
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