Evidence map›Paper›PMID 42278462›Full record

ArticleInternational journal of molecular sciences2026

Comparative ESEM Characterization and Collagen-Related Tissue Responses to Commercial Injectable Bioregenerative Formulations in a Murine Model.

Anna Paula Silva Dias Marcondes, Fernando Veloso Caldeira Barcellos, Maria Rafaela Pereira Lacerda, Andréia Luiza Oliveira Costa, Lorena Dos Reis Pereira Queiroz, Jhenifer Rocha Oliveira, Bruno Gorayski Milo, Tatiany Bertollo Cozer Ribeiro da Costa, Sérgio Henrique Sousa Santos, Lucyana Conceição Farias and 2 more

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Anna Paula Silva Dias MarcondesDepartment of Dentistry, Universidade Estadual de Montes Claros (Unimontes), Montes Claros 39401-089, Minas Gerais, Brazil.
Fernando Veloso Caldeira BarcellosDepartment of Dentistry, Universidade Estadual de Montes Claros (Unimontes), Montes Claros 39401-089, Minas Gerais, Brazil.ORCID 0009-0006-0005-1512
Maria Rafaela Pereira LacerdaDepartment of Dentistry, Universidade Estadual de Montes Claros (Unimontes), Montes Claros 39401-089, Minas Gerais, Brazil.ORCID 0009-0007-2539-1481
Andréia Luiza Oliveira CostaDepartment of Dentistry, Universidade Estadual de Montes Claros (Unimontes), Montes Claros 39401-089, Minas Gerais, Brazil.ORCID 0000-0002-5870-2502
Lorena Dos Reis Pereira QueirozDepartment of Dentistry, Universidade Estadual de Montes Claros (Unimontes), Montes Claros 39401-089, Minas Gerais, Brazil.ORCID 0000-0001-9082-545X
Jhenifer Rocha OliveiraDepartment of Dentistry, Universidade Estadual de Montes Claros (Unimontes), Montes Claros 39401-089, Minas Gerais, Brazil.ORCID 0009-0007-4426-0671
Bruno Gorayski MiloDepartment of Dentistry, Universidade Estadual de Montes Claros (Unimontes), Montes Claros 39401-089, Minas Gerais, Brazil.ORCID 0009-0000-4959-0644
Tatiany Bertollo Cozer Ribeiro da CostaDepartment of Dentistry, Universidade Estadual de Montes Claros (Unimontes), Montes Claros 39401-089, Minas Gerais, Brazil.
Sérgio Henrique Sousa SantosInstitute of Agricultural Sciences, Universidade Federal de Minas Gerais (UFMG), Montes Claros 39404-547, Minas Gerais, Brazil.ORCID 0000-0002-7788-5447
Lucyana Conceição FariasDepartment of Dentistry, Universidade Estadual de Montes Claros (Unimontes), Montes Claros 39401-089, Minas Gerais, Brazil.
Alfredo Maurício Batista de PaulaDepartment of Dentistry, Universidade Estadual de Montes Claros (Unimontes), Montes Claros 39401-089, Minas Gerais, Brazil.
André Luiz Sena GuimarãesDepartment of Dentistry, Universidade Estadual de Montes Claros (Unimontes), Montes Claros 39401-089, Minas Gerais, Brazil.

Funding

Coordenação de Aperfeicoamento de Pessoal de Nível Superior Not applicableFundação de Amparo à Pesquisa do Estado de Minas Gerais Not applicableNational Council for Scientific and Technological Development Not applicable
6 · The paper itself

Abstract

Dermal senescence is associated with reduced fibroblast activity, decreased extracellular matrix synthesis, and impaired tissue repair. Commercial injectable formulations containing poly-L-lactic acid (PLLA), hyaluronic acid (HA), and polydeoxyribonucleotide (PDRN)-associated compounds have been proposed for dermal remodeling approaches and modulate tissue-response pathways; however, comparative studies evaluating commercially available formulations under standardized experimental conditions remain limited. This study aimed to characterize the morphology of formulations containing PLLA, HA, and PDRN, used alone or in combination, by environmental scanning electron microscopy (ESEM), and to investigate formulation-associated histological and collagen-related molecular responses in a murine model. Formulations containing PLLA, HA, HA + PDRN, and PLLA, HA and PDRN were administered into the dorsal subcutaneous tissue of 14

Indexed as

Biocompatible MaterialsCollagenHyaluronic AcidPolydeoxyribonucleotidesPolyestersAnimalsCollagen Type ICollagen Type I, alpha 1 ChainMaleMiceMicroscopy, Electron, ScanningSkinSkin AgingBiocompatible MaterialsCollagenCollagen Type ICollagen Type I, alpha 1 ChainHyaluronic AcidPolydeoxyribonucleotidesPolyesterspoly(lactide)bioregenerative formulationsdermal remodelinghyaluronic acidpolydeoxyribonucleotidepoly-L-lactic acid

Identifiers

PMID42278462
PMCPMC13256218

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.