Evidence map›Paper›PMID 42278434›Full record

ArticleInternational journal of molecular sciences2026

EV-Finder: Direct Detection of Extracellular Vesicle-Associated Proteins by Proximity Extension Assay for Multi-Cancer Screening.

Yoshitaka Tamai, Fumiko Chiwaki, Yurika Shiotani, Hye-Eun Park, Eun-Jung Jung, Myung-Geun Shin, Young-Eun Lee, Yusuke Yoshioka, Takahiro Ochiya, Taek-Rim Yoon

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yoshitaka TamaiMedical Institute for Translational Health Science, ASFREYA Inc., 2-3-8 Shinkiba, Koto-ku, Tokyo 136-0082, Japan.
Fumiko ChiwakiMedical Institute for Translational Health Science, ASFREYA Inc., 2-3-8 Shinkiba, Koto-ku, Tokyo 136-0082, Japan.
Yurika ShiotaniMedical Institute for Translational Health Science, ASFREYA Inc., 2-3-8 Shinkiba, Koto-ku, Tokyo 136-0082, Japan.
Hye-Eun ParkR&D Center, Exopia Co., Ltd., Room 210, Advanced Precision Medicine Industrialization Support Center, Chonnam National University Hwasun Hospital, 322, Seoyang-ro, Hwasun-eup, Hwasun-gun 58128, Republic of Korea.
Eun-Jung JungR&D Center, Exopia Co., Ltd., Room 210, Advanced Precision Medicine Industrialization Support Center, Chonnam National University Hwasun Hospital, 322, Seoyang-ro, Hwasun-eup, Hwasun-gun 58128, Republic of Korea.
Myung-Geun ShinDepartment of Laboratory Medicine, Chonnam National University Medical School, Chonnam National University Hwasun Hospital, 322, Seoyang-ro, Hwasun-eup, Hwasun-gun 58128, Republic of Korea.ORCID 0000-0002-0372-9185
Young-Eun LeeDepartment of Laboratory Medicine, Chonnam National University Medical School, Chonnam National University Hwasun Hospital, 322, Seoyang-ro, Hwasun-eup, Hwasun-gun 58128, Republic of Korea.ORCID 0000-0003-2700-3087
Yusuke YoshiokaDepartment of Molecular and Cellular Medicine, Institute of Medical Science, Tokyo Medical University, 6-1-1 Shinjuku, Shinjuku-ku, Tokyo 160-8402, Japan.
Takahiro OchiyaMedical Institute for Translational Health Science, ASFREYA Inc., 2-3-8 Shinkiba, Koto-ku, Tokyo 136-0082, Japan.
Taek-Rim YoonR&D Center, Exopia Co., Ltd., Room 210, Advanced Precision Medicine Industrialization Support Center, Chonnam National University Hwasun Hospital, 322, Seoyang-ro, Hwasun-eup, Hwasun-gun 58128, Republic of Korea.

Funding

Japan Agency for Medical Research and Development JP20cm0106402Japan Agency for Medical Research and Development JP22ama221405
6 · The paper itself

Abstract

Early cancer detection using minimally invasive biomarkers remains a significant challenge, particularly in early-stage disease, where circulating tumor DNA is often below the limit of detection. Extracellular vesicles (EVs), which are actively secreted by viable cancer cells and carry tumor-associated proteins, represent a promising alternative target for liquid biopsy. In this study, we developed EV-finder

Indexed as

Biomarkers, TumorEarly Detection of CancerExtracellular VesiclesNeoplasmsHumansMachine LearningBiomarkers, TumorEV-associated proteinsextracellular vesiclesliquid biopsymachine learningmulti-cancer screening

Identifiers

PMID42278434
PMCPMC13256567

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.