ArticleInternational journal of molecular sciences2026
Expression of Axonal Transport Proteins in Dopaminergic Neurons of the Substantia Nigra in Mouse Models of Preclinical and Clinical Stages of Parkinson's Disease.
Anna Kolacheva, Dmitry Troshev, Alyona Antonova, Ekaterina Pavlova, Vsevolod Bogdanov, Varvara Kalashnikova, Anna Popova, Maria Shchepina, Michael Ugrumov
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In one paragraphArticle in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
9 authors.
Anna KolachevaLaboratory of Neural and Neuroendocrine Regulations, Koltzov Institute of Developmental Biology, Russian Academy of Sciences, 26 Vavilova Street, 119334 Moscow, Russia.
Dmitry TroshevLaboratory of Neural and Neuroendocrine Regulations, Koltzov Institute of Developmental Biology, Russian Academy of Sciences, 26 Vavilova Street, 119334 Moscow, Russia.ORCID 0000-0001-5948-9339 Alyona AntonovaLaboratory of Neural and Neuroendocrine Regulations, Koltzov Institute of Developmental Biology, Russian Academy of Sciences, 26 Vavilova Street, 119334 Moscow, Russia.
Ekaterina PavlovaLaboratory of Neural and Neuroendocrine Regulations, Koltzov Institute of Developmental Biology, Russian Academy of Sciences, 26 Vavilova Street, 119334 Moscow, Russia.ORCID 0000-0001-5662-3715 Vsevolod BogdanovLaboratory of Neural and Neuroendocrine Regulations, Koltzov Institute of Developmental Biology, Russian Academy of Sciences, 26 Vavilova Street, 119334 Moscow, Russia.ORCID 0009-0004-8676-0381 Varvara KalashnikovaLaboratory of Neural and Neuroendocrine Regulations, Koltzov Institute of Developmental Biology, Russian Academy of Sciences, 26 Vavilova Street, 119334 Moscow, Russia.
Anna PopovaThe Institute of Digital Biodesign and Artificial Intelligence in Medicine, I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation, 8-2 Trubetskaya Street, 119991 Moscow, Russia.
Maria ShchepinaLaboratory of Neural and Neuroendocrine Regulations, Koltzov Institute of Developmental Biology, Russian Academy of Sciences, 26 Vavilova Street, 119334 Moscow, Russia.ORCID 0000-0002-4725-832X Michael UgrumovLaboratory of Neural and Neuroendocrine Regulations, Koltzov Institute of Developmental Biology, Russian Academy of Sciences, 26 Vavilova Street, 119334 Moscow, Russia.
Funding
Russian Science Foundation 24-74-10054
6 · The paper itselfAbstract
Impairment of axonal transport may contribute to the degeneration of dopaminergic (DAergic) neurons in the substantia nigra (SN), a key event in Parkinson's disease (PD) pathogenesis. Due to the lack of early diagnosis, changes in axonal transport at the preclinical stage can only be studied in PD models. We assessed gene expression (RT-PCR after cell sorting) and protein levels (semiquantitative immunohistochemistry) of axonal transport-related proteins in SN DAergic neurons from mice in subchronic MPTP models of PD (preclinical and clinical stages) and controls. The proteins studied included α-tubulin (
Indexed as
Axonal TransportDopaminergic NeuronsParkinson DiseaseSubstantia NigraAnimalsDisease Models, AnimalDynactin ComplexDyneinsGene Expression RegulationKinesinsMaleMiceMice, Inbred C57BLtau ProteinsTubulinDctn1 protein, mouseDynactin ComplexDyneinsKinesinstau ProteinsTubulinaxonal transportdopaminergic neuronsdyneinkinesinmicrotubuleMPTPParkinson’s diseasepreclinical and clinical stages
Identifiers
PMID42278423
PMCPMC13257252
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