Menin Inhibition in Acute Myeloid Leukemia: Rewiring Leukemic Transcriptional Networks.

Ali Tarhini, Michael Romanos, Aref Al-Kali, Antoine N Saliba

Abstract readReview

In one paragraph

Review in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ali TarhiniDepartment of Oncology, Mayo Clinic, Rochester, MN 55905, USA.ORCID 0009-0002-0086-0556

Michael RomanosDepartment of Medicine, Mayo Clinic, Rochester, MN 55905, USA.

Aref Al-KaliDivision of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA.ORCID 0000-0002-0824-3715

Antoine N SalibaDivision of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA.ORCID 0000-0001-5134-7336

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Among the transcriptional dependencies that sustain leukemic identity in acute myeloid leukemia (AML), the menin-KMT2A chromatin complex has emerged as a central regulatory node. The scaffold protein menin, encoded by

Indexed as

Gene Expression Regulation, LeukemicGene Regulatory NetworksLeukemia, Myeloid, AcuteProto-Oncogene ProteinsAnimalsHistone-Lysine N-MethyltransferaseHumansMyeloid-Lymphoid Leukemia ProteinNucleophosminHistone-Lysine N-MethyltransferaseKMT2A protein, humanMEN1 protein, humanMyeloid-Lymphoid Leukemia ProteinNPM1 protein, humanNucleophosminProto-Oncogene Proteinsacute myeloid leukemiaHOXA/MEIS1KMT2A rearrangementmenin inhibitorsNPM1 mutation

Identifiers

PMID42278415

DOI10.3390/ijms27114886

PMCPMC13256885

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.