Evidence map›Paper›PMID 42278383›Full record

ArticleInternational journal of molecular sciences2026

Single-Nucleotide Polymorphisms in Genes Associated with Mitochondrial and DNA Damage Response Modulate the Risk of Non-Alcoholic Fatty Liver Disease in Humans.

Sylwia Ziółkowska, Marcin Kosmalski, Łukasz Kołodziej, Kinga Jarmusz, Magdalena Ejsmont, Tadeusz Pietras, Aleksandra Jabłkowska, Maciej Jabłkowski, Janusz Szemraj, Piotr Czarny

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Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Sylwia ZiółkowskaDepartment of Medical Biochemistry, Medical University of Lodz, 92-215 Lodz, Poland.ORCID 0000-0001-8140-3853
Marcin KosmalskiDepartment of Clinical Pharmacology, Medical University of Lodz, 90-153 Lodz, Poland.ORCID 0000-0003-0609-9657
Łukasz KołodziejDepartment of Molecular Genetics, Faculty of Biology and Environmental Protection, University of Lodz, 90-236 Lodz, Poland.ORCID 0000-0002-8607-7097
Kinga JarmuszDepartment of Medical Biochemistry, Medical University of Lodz, 92-215 Lodz, Poland.
Magdalena EjsmontDepartment of Medical Biochemistry, Medical University of Lodz, 92-215 Lodz, Poland.
Tadeusz PietrasDepartment of Clinical Pharmacology, Medical University of Lodz, 90-153 Lodz, Poland.
Aleksandra JabłkowskaDepartment of Infectious and Liver Diseases, Medical University of Lodz, 91-347 Lodz, Poland.ORCID 0000-0001-9854-5233
Maciej JabłkowskiDepartment of Infectious and Liver Diseases, Medical University of Lodz, 91-347 Lodz, Poland.
Janusz SzemrajDepartment of Medical Biochemistry, Medical University of Lodz, 92-215 Lodz, Poland.ORCID 0000-0001-6052-3557
Piotr CzarnyDepartment of Medical Biochemistry, Medical University of Lodz, 92-215 Lodz, Poland.ORCID 0000-0002-5146-5225

Funding

National Science Centre 2019/35/O/NZ5/02502
6 · The paper itself

Abstract

Non-alcoholic fatty liver disease (NAFLD) is one of the most common chronic liver disorders and has been linked to oxidative stress. Therefore, it can be hypothesized that NAFLD may be associated with genes encoding proteins involved in the base-excision repair (BER) pathway. Moreover, mitochondrial dysfunction plays a significant role in the development of NAFLD. In light of these observations, we suggested that fatty liver may be associated with genes that encode proteins responsible for mitochondrial DNA (mtDNA) degradation. This study evaluates single-nucleotide polymorphisms (SNPs) within the

Indexed as

DNA DamageDNA, MitochondrialGenetic Predisposition to DiseaseMitochondriaNon-alcoholic Fatty Liver DiseasePolymorphism, Single NucleotideAdultCase-Control StudiesDNA Polymerase gammaDNA RepairExcision RepairFemaleFlap EndonucleasesHaplotypesHumansMaleDNA, MitochondrialDNA Polymerase gammaFEN1 protein, humanFlap EndonucleasesPARP1 protein, humanPOLG protein, humanPoly (ADP-Ribose) Polymerase-1X-ray Repair Cross Complementing Protein 1XRCC1 protein, humanDNA repairmitochondrial DNAmitochondrial DNA degradationSNP genotypingsteatosis

Identifiers

PMID42278383
PMCPMC13256566

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.