Evidence map›Paper›PMID 42278364›Full record

ArticleInternational journal of molecular sciences2026

Pistachio Leaf Extract Modulates Redox-Dependent Mitochondrial and Metabolic Responses in Ethanol-Stressed HepG2 Cells.

Enrico La Spina, Emanuela Tropea, Annalisa Santisi, Alfio Distefano, Lucia Longhitano, Giuseppe Antonio Malfa, Cesarina Giallongo, Giuseppe Alberto Palumbo, Giovanni Li Volti, Daniele Tibullo and 1 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Enrico La SpinaDepartment of Biotechnological and Biomedical Sciences, University of Catania, 95123 Catania, Italy.ORCID 0000-0002-8483-4680
Emanuela TropeaDepartment of Biotechnological and Biomedical Sciences, University of Catania, 95123 Catania, Italy.
Annalisa SantisiDepartment of Medical and Surgical Sciences and Advanced Technologies "G.F. Ingrassia", University of Catania, 95123 Catania, Italy.
Alfio DistefanoDepartment of Biotechnological and Biomedical Sciences, University of Catania, 95123 Catania, Italy.ORCID 0000-0003-3323-9344
Lucia LonghitanoDepartment of Biotechnological and Biomedical Sciences, University of Catania, 95123 Catania, Italy.
Giuseppe Antonio MalfaDepartment of Drug Science-Biochemistry Section, University of Catania, Viale A. Doria 6, 95125 Catania, Italy.ORCID 0000-0002-6733-0587
Cesarina GiallongoDepartment of Biotechnological and Biomedical Sciences, University of Catania, 95123 Catania, Italy.
Giuseppe Alberto PalumboDepartment of Medical and Surgical Sciences and Advanced Technologies "G.F. Ingrassia", University of Catania, 95123 Catania, Italy.ORCID 0000-0003-1859-6319
Giovanni Li VoltiDepartment of Biotechnological and Biomedical Sciences, University of Catania, 95123 Catania, Italy.ORCID 0000-0002-8678-2183
Daniele TibulloDepartment of Biotechnological and Biomedical Sciences, University of Catania, 95123 Catania, Italy.ORCID 0000-0002-4416-8556
Ignazio Alberto BarbagalloDepartment of Biotechnological and Biomedical Sciences, University of Catania, 95123 Catania, Italy.ORCID 0000-0002-7761-0662

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ethanol-induced hepatocellular injury is characterized by redox imbalance and mitochondrial dysfunction, which critically determine cellular adaptation to metabolic stress. Rather than acting as simple antioxidants, effective nutraceutical strategies may enhance endogenous adaptive responses that preserve cellular homeostasis. Pistachio (

Indexed as

EthanolMitochondriaPistaciaPlant ExtractsPlant LeavesCell SurvivalGlutathioneHep G2 CellsHumansOxidation-ReductionOxidative StressReactive Oxygen SpeciesEthanolGlutathionePlant ExtractsReactive Oxygen Speciesalcohol metabolismEtOH-induced cytotoxicityhepatocellular homeostasisPistacia vera L.redox homeostasis

Identifiers

PMID42278364
PMCPMC13256378

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.