Bacterial Acyl Carrier Proteins Are a Cytoplasmic Target for Different Cationic Antimicrobial and Antibiofilm Peptides.

Gopal Ramamourthy, Subrata Paul, Ishrat M Jalal, Hiroaki Ishida, Hans J Vogel

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Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

5 authors.

Gopal RamamourthyBiochemistry Research Group, Department of Biological Sciences, University of Calgary, Calgary, AB T2N 1N4, Canada.

Subrata PaulBiochemistry Research Group, Department of Biological Sciences, University of Calgary, Calgary, AB T2N 1N4, Canada.ORCID 0009-0002-4107-9264

Ishrat M JalalBiochemistry Research Group, Department of Biological Sciences, University of Calgary, Calgary, AB T2N 1N4, Canada.ORCID 0000-0001-7954-9757

Hiroaki IshidaBiochemistry Research Group, Department of Biological Sciences, University of Calgary, Calgary, AB T2N 1N4, Canada.

Hans J VogelBiochemistry Research Group, Department of Biological Sciences, University of Calgary, Calgary, AB T2N 1N4, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cationic antimicrobial peptides (AMPs) that can target multidrug-resistant pathogenic bacteria via multiple mechanisms are considered promising alternatives to antibiotics. Small (~9 kDa) highly acidic acyl carrier proteins (ACPs), which are a well-known cofactor protein in bacterial fatty acid synthesis (FAS), are a potential intracellular target for AMPs. A previous study has demonstrated that the human AMP LL-37 can bind to ACP and thereby affect FAS and the bacterial membrane integrity. In this work, we have investigated the interactions of different classes of AMPs and antibiofilm peptides (ABPs) with the ACPs of two pathogens. We first studied the folding characteristics of the two ACPs and found that

Indexed as

Acyl Carrier ProteinAntimicrobial Cationic PeptidesAntimicrobial PeptidesBacterial ProteinsBiofilmsAnti-Bacterial AgentsCytoplasmHumansProtein FoldingPseudomonas aeruginosaAcyl Carrier ProteinAnti-Bacterial AgentsAntimicrobial Cationic PeptidesAntimicrobial PeptidesBacterial Proteinsacyl carrier proteinantibiofilm peptidesantimicrobial peptidesFrancisella novicidaPseudomonas aeruginosa

Identifiers

PMID42278354

DOI10.3390/ijms27114823

PMCPMC13256389

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LicenceCC BY

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.