Evidence map›Paper›PMID 42278338›Full record

ArticleInternational journal of molecular sciences2026

Aaron Embry, Emily A Rex, David F Schad, Daniel M Deng, Neal M Alto, Don B Gammon

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Aaron EmbryDepartment of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Emily A RexDepartment of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0002-1057-3836
David F SchadDepartment of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Daniel M DengDepartment of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Neal M AltoDepartment of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Don B GammonDepartment of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0003-1144-4152

Funding

MOLECULAR MICROBIOLOGY TRAINING GRANTT32AI007520 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI Julie K Pfeiffer · 1997 to 2026
$7.0M
Type III effector regulation of host signal transduction systemsR01AI083359 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI ALTO, NEAL MATHEW · 2009 to 2024
$6.3M
Exploiting Pathogen-Encoded Immune Evasion Proteins to Uncover Evolutionarily Conserved Antiviral Host MachineryR35GM137978 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI Don Brad Gammon · 2020 to 2026
$2.5M
Using Bacterial Effectors to Uncover Innate Immune Mechanisms Restricting Viral Replication in Bat CellsR21AI169558 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI GAMMON, DON BRAD · 2023 to 2024
$451k
National Institute of Allergy and Infectious Diseases R01AI083359National Institute of Allergy and Infectious Diseases R21AI169558NIAID NIH HHS R01 AI083359NIAID NIH HHS R21 AI169558NIAID NIH HHS T32 AI007520NIGMS NIH HHS R35GM137978Welch Foundation I-1704
6 · The paper itself

Abstract

Arthropod-borne viruses (arboviruses) cause a wide range of acute and chronic diseases and represent a growing global health burden. Although some vaccines exist, antiviral therapies remain limited. Identifying host restriction factors may enable new therapeutic strategies. We previously showed that bacterial effector proteins can serve as tools to uncover innate immune defenses. Here, we used a bacterial effector screen in bat cells to identify host factors restricting the arboviruses Sindbis virus (SINV) and O'nyong'nyong virus (ONNV). Several effectors enhanced infection by both viruses. However, we found the

Indexed as

Alphavirus InfectionsBacterial ProteinsHost-Pathogen InteractionsShigella flexneriSindbis VirusUbiquitin-Protein LigasesAnimalsCell LineHumansVirus ReplicationBacterial ProteinsUbiquitin-Protein Ligasesantiviral immunitybacterial effectorsE3 ubiquitin ligaseShigella flexneriSindbis virustogavirus

Identifiers

PMID42278338
PMCPMC13256859

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.