ArticleInternational journal of molecular sciences2026
The Subepithelial Bandlike Distribution Pattern of the CD4 Biomarker May Determine Oral Lichen Planus in the Absence of Typical Microscopic Features.
Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Given higher compatible rates between oral lichen planus (OLP) and oral lichenoid lesions (OLLs) in histopathological and clinical features, this study aims to delineate a boundary between equivocal OLP and OLLs by biomarkers. The updated OLP diagnostic criteria in 2016 was our guideline in defining study cases of typical OLP and typical OLL with triggers, which include topical offending agents (OLL-agent), dental restorations (OLL-dental), and systemic offending drugs (OLL-drug). The expression intensity and distribution patterns of CD4, CD8, and CGRP in four groups were detected by immunohistochemistry assay (IHC). A total of 79 cases including OLP (24), OLL-agent (15), OLL-dental (21), and OLL-drug (19) were collected from an oral biopsy laboratory. Band-like distribution patterns of CD4 (100%, score 3), CD8 (54.17%, score 2), and CGRP (87.5%, score 3) in the subepithelial regions of the OLP group significantly differ from the OLL groups (each comparison pair,
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