Dissection of the EIAV Core Packaging Region Identifies SL2 Stem and SL2-SL3 Junction as Gag-Associated Packaging Determinants and Antiviral Targets.

Qiyan Chen, Rui Li, Li Wang, Jinzhong Wang, Ying Wang

Abstract read

In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Qiyan ChenTEDA Institute of Biological Sciences and Biotechnology, Nankai University, 23 Hongda Street, TEDA, Tianjin 300457, China.

Rui LiTEDA Institute of Biological Sciences and Biotechnology, Nankai University, 23 Hongda Street, TEDA, Tianjin 300457, China.

Li WangTEDA Institute of Biological Sciences and Biotechnology, Nankai University, 23 Hongda Street, TEDA, Tianjin 300457, China.

Jinzhong WangTEDA Institute of Biological Sciences and Biotechnology, Nankai University, 23 Hongda Street, TEDA, Tianjin 300457, China.

Ying WangTEDA Institute of Biological Sciences and Biotechnology, Nankai University, 23 Hongda Street, TEDA, Tianjin 300457, China.ORCID 0000-0002-4990-8154

Funding

Natural Science Foundation of China 30970140

6 · The paper itself

Abstract

Equine infectious anemia virus (EIAV), with the simplest lentiviral genome, is a key model for studying fundamental lentiviral biology. Infectious viral particles are produced only when the Gag protein selectively encapsidates full-length genomic RNA via the packaging signal (Psi), yet the structural and functional features of EIAV Psi remain poorly characterized. Using computational prediction and dimethyl sulfate probing, we identified four stem-loops (SLs) within a ~120 nt region in the 5' leader of the genome, spanning from downstream of the primer binding site through 20 nt into the

Indexed as

Gene Products, gagInfectious Anemia Virus, EquineRNA, ViralVirus AssemblyAnimalsAntiviral AgentsHorsesInverted Repeat SequencesNucleic Acid ConformationVirus ReplicationAntiviral AgentsGene Products, gagRNA, Viralantisense oligonucleotidesequine infectious anemia viruspackaging signalRNA dimerizationstem-loops

Identifiers

PMID42278261

DOI10.3390/ijms27114728

PMCPMC13257266

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.