Evidence map›Paper›PMID 42278194›Full record

ArticleInternational journal of molecular sciences2026

Pregabalin Depresses Cerebellar Parallel Fiber-Purkinje Cell Synaptic Transmission by Modulating Glun2a-Containing Nmda Receptors in Mice In Vitro.

Mei-Rui Li, Xu-Dong Zhang, Li Chen, Yi-Dan Zhang, Chun-Yan Wang, Zi-Yu Zhao, Mo Zhou, Chun-Ping Chu, De-Lai Qiu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mei-Rui LiDepartment of Physiology and Pathophysiology, College of Medicine, Yanbian University, Yanji 133002, China.
Xu-Dong ZhangDepartment of Physiology and Pathophysiology, College of Medicine, Yanbian University, Yanji 133002, China.
Li ChenDepartment of Physiology and Pathophysiology, College of Medicine, Yanbian University, Yanji 133002, China.
Yi-Dan ZhangDepartment of Physiology and Pathophysiology, College of Medicine, Yanbian University, Yanji 133002, China.
Chun-Yan WangInstitute of Brain Science, Jilin Medical University, Jilin 132013, China.
Zi-Yu ZhaoInstitute of Brain Science, Jilin Medical University, Jilin 132013, China.
Mo ZhouInstitute of Brain Science, Jilin Medical University, Jilin 132013, China.
Chun-Ping ChuInstitute of Brain Science, Jilin Medical University, Jilin 132013, China.ORCID 0009-0006-6921-5028
De-Lai QiuDepartment of Physiology and Pathophysiology, College of Medicine, Yanbian University, Yanji 133002, China.ORCID 0000-0001-8825-4707

Funding

the Major Projects of the Ministry of Science and Technology of China 2021ZD0202300the National Natural Science Foundations of China 32171005
6 · The paper itself

Abstract

Pregabalin (PGB) exerts its therapeutic effects by binding to the α

Indexed as

CerebellumPregabalinPurkinje CellsReceptors, N-Methyl-D-AspartateSynaptic TransmissionAnimalsExcitatory Postsynaptic PotentialsGlutamic AcidMaleMiceMice, Inbred C57BLGlutamic AcidPregabalinReceptors, N-Methyl-D-Aspartatecerebellar parallel fiberexcitatory postsynaptic currents (EPSCs)gluN2A-containing NMDA receptorminiature excitatory postsynaptic currents (mEPSCs)pregabalinprotein kinase A (PKA)Purkinje cell

Identifiers

PMID42278194
PMCPMC13257390

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.