Evidence map›Paper›PMID 42278139›Full record

ArticleAnimals : an open access journal from MDPI2026

Development and Preliminary Evaluation of an OMP16-Targeting Trivalent Nanobody-HRP-Based cELISA for Serological Detection of Bovine Brucellosis.

Gaowa Wudong, Qing Lu, Yunyi Zhai, Ye Yuan, Xiaofang Liu, Yuanhao Yang, Lu Zhang, Yaping Jin, Dong Zhou, Aihua Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Animals : an open access journal from MDPI, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Gaowa WudongCollege of Veterinary Medicine, Northwest A&F University, Xianyang 712100, China.
Qing LuCollege of Veterinary Medicine, Northwest A&F University, Xianyang 712100, China.
Yunyi ZhaiCollege of Veterinary Medicine, Northwest A&F University, Xianyang 712100, China.
Ye YuanCollege of Veterinary Medicine, Northwest A&F University, Xianyang 712100, China.
Xiaofang LiuCollege of Veterinary Medicine, Northwest A&F University, Xianyang 712100, China.
Yuanhao YangCollege of Veterinary Medicine, Northwest A&F University, Xianyang 712100, China.
Lu ZhangCollege of Veterinary Medicine, Northwest A&F University, Xianyang 712100, China.
Yaping JinCollege of Veterinary Medicine, Northwest A&F University, Xianyang 712100, China.
Dong ZhouCollege of Veterinary Medicine, Northwest A&F University, Xianyang 712100, China.
Aihua WangCollege of Veterinary Medicine, Northwest A&F University, Xianyang 712100, China.

Funding

Science and Technology Department of Ningxia 2018BBF33001
6 · The paper itself

Abstract

Brucellosis is a globally prevalent zoonotic disease that imposes considerable economic burdens on the livestock industry and remains a significant threat to public health. Although lipopolysaccharide (LPS)-based serological assays are widely used in routine diagnosis, their inherent limitations-particularly cross-reactivity with other Gram-negative bacteria-underscore the need for the development of diagnostic approaches based on non-LPS antigens. In this study, we developed a trivalent nanobody-horseradish peroxidase (3Nbs-HRP) fusion protein targeting

Indexed as

3Nbs-HRPBrucellacELISAOMP16

Identifiers

PMID42278139
PMCPMC13255959

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.