ArticleAnimals : an open access journal from MDPI2026
The Effects of Arginine, Guanidinoacetic Acid and Citrulline Supplementation to Reduced Protein Diets for Aged Laying Hens.
Article in Animals : an open access journal from MDPI, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
7 authors.
Funding
Abstract
This study evaluated the effects of arginine (Arg), guanidinoacetic acid (GAA), and citrulline (Cit) supplementation in reduced protein (RP) diets on the production performance, serum uric acid level and bone quality of aged laying hens. A total of 208 Hy-Line Brown laying hens from 60 to 75 weeks of age were assigned to eight dietary treatments, with 13 replicate cages per treatment and two hens per cage. Experimental diets comprised two protein levels (standard protein at 15.8% crude protein versus RP at 13.8% crude protein), and six RP diets supplemented with two inclusion levels (0.06% and 0.12%) of Arg, GAA, or Cit. Overall, increasing Cit supplementation improved productive performance compared with Arg and GAA, particularly by increasing egg weight (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.