ArticleMagnetic resonance in medicine2026
Whole-Body Oxygen-Enhanced MRI of Tumor-Bearing Mice Under Hyperbaric Oxygenation.
Article in Magnetic resonance in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeOxygen-enhanced MRI (OE-MRI) enables noninvasive assessment of tissue oxygenation by exploiting the paramagnetic effect of molecular oxygen on longitudinal relaxation. The purpose of this study was to evaluate whether whole-body oxygen-enhanced MRI (OE-MRI) can be performed under hyperbaric oxygen (HBO) conditions and to assess its utility for detecting oxygenation changes in a small-animal tumor model using a clinical 3 T scanner.
methodsA fully MRI-compatible HBO chamber was built for imaging mice and installed in a 3 T clinical scanner. SCC7-tumor-bearing C3H mice underwent whole-body OE-MRI with variable flip-angle T
resultsHigh-quality OE-MRI was obtained under all hyperbaric conditions. Normal tissues (brain, heart) showed uniform, pressure-dependent increases in ΔR
conclusionWhole-body pre-clinical OE-MRI on a clinical 3 T system is feasible and sensitive under hyperbaric oxygenation, capturing both tissue-level pressure effects and heterogeneous tumor oxygen responses. This non-invasive HBO-OE-MRI platform provides a valuable pre-clinical tool for assessing oxygen delivery and identifying oxygen-refractory tumor zones, supporting oxygen-guided therapeutic strategies.
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